Objective Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of antimicrobial resistance (AMR) have lacked a holistic view combining all aspects into one study. The SATURN project aims to study the impact of antibiotic exposure on AMR with a multidisciplinary approach that bridges molecular, epidemiological, clinical and pharmacological research. Two types of clinical studies will be conducted: First, a randomized trial will be performed to resolve an issue of high controversy (antibiotic cycling vs. mixing). Second, 3 observational studies will be conducted to rigorously study issues surrounding the effect of antibiotic use on AMR that are not easily assessable through randomized trials. These clinical studies will serve as a platform to 2 complementary workpackages (microbiology & pharmacology) that will perform important investigations relevant to this call. The work package focusing on molecular studies will generate new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. The purpose of the pharmacodynamic study is to model the relationships between antibiotic exposure and AMR emergence over time for various classes of agents. In summary, the overarching rationale of SATURN is to improve methodological standards and conduct research that will help to better understand the impact of antibiotic use on acquisition, selection and transmission of AMR in different environments, by combining analyses of molecular, individual patient-level and ecologic data. The anticipated results may guide clinical and policy decisions to ultimately reduce the burden of AMR in Europe. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2009-2.3.1-2 - Impact of specific antibiotic therapies on the prevalence of resistant bacteria in the human host Call for proposal FP7-HEALTH-2009-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITE DE GENEVE EU contribution € 684 400,00 Address RUE DU GENERAL DUFOUR 24 1211 Geneve Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Stephan Jurgen Harbarth (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all STICHTING NIJMEEGS INTERCONFESSIONEEL ZIEKENHUIS CANISIUS WILHELMINA Participation ended Netherlands EU contribution No data Address WEG DOOR JONKERBOS 100 6532SZ NIJMEGEN See on map Activity type Research Organisations Administrative Contact Johan Willem Mouton (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSYTET MEDYCZNY W LODZI. Poland EU contribution € 178 761,80 Address Al. Kosciuszki, 4 90419 Lodz See on map Region Makroregion centralny Łódzkie Łódzki Activity type Higher or Secondary Education Establishments Administrative Contact Maciej Godycki-Cwirko (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV Israel EU contribution € 922 947,00 Address WEIZMANN STREET 6 64239 Tel Aviv See on map Activity type Research Organisations Administrative Contact Michal Roll (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT ANTWERPEN Belgium EU contribution € 1 017 911,00 Address PRINSSTRAAT 13 2000 Antwerpen See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Administrative Contact Anne Adams (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA CATTOLICA DEL SACRO CUORE Italy EU contribution € 592 349,60 Address LARGO GEMELLI 1 20123 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Filippo Leone (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 806 190,00 Address HEIDELBERGLAAN 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Anne-Marie Laeven (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC France EU contribution € 374 041,30 Address 39 RUE DES MATHURINS 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eric Papon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution € 267 567,80 Address CALLE ROSSELLO 149 PUERTA BJS 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Ramon Gomis (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDATION HOPITAL SAINT JOSEPH Participation ended France EU contribution € 7 451,86 Address RUE RAYMOND LOSSERAND 185 75674 PARIS See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Philippe Fradin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Germany EU contribution € 212 987,00 Address SANDERRING 2 97070 Wuerzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Christian Gloggengiesser (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Clinical Center of Serbia Serbia EU contribution € 145 103,30 Address Pasterova 2 11000 Belgrade See on map Activity type Higher or Secondary Education Establishments Administrative Contact Zivan Maksimovic (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUTUL NATIONAL DE BOLI INFECTIOASE PROF DR MATEI BALS BUCURESTI Romania EU contribution € 145 975,00 Address STR DR GROZOVICI 1 021105 Bucuresti See on map Region Macroregiunea Trei Bucureşti-Ilfov Bucureşti Activity type Research Organisations Administrative Contact Daniela Dumitrascu (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 373 549,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Johan Willem Mouton (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 235 389,74 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Christophe Misse (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 34 811,60 Address GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Evelina Tacconelli (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
