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Impact of Specific Antibiotic Therapies on the prevalence of hUman host ResistaNt bacteria

Objective

Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of antimicrobial resistance (AMR) have lacked a holistic view combining all aspects into one study. The SATURN project aims to study the impact of antibiotic exposure on AMR with a multidisciplinary approach that bridges molecular, epidemiological, clinical and pharmacological research. Two types of clinical studies will be conducted: First, a randomized trial will be performed to resolve an issue of high controversy (antibiotic cycling vs. mixing). Second, 3 observational studies will be conducted to rigorously study issues surrounding the effect of antibiotic use on AMR that are not easily assessable through randomized trials. These clinical studies will serve as a platform to 2 complementary workpackages (microbiology & pharmacology) that will perform important investigations relevant to this call. The work package focusing on molecular studies will generate new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. The purpose of the pharmacodynamic study is to model the relationships between antibiotic exposure and AMR emergence over time for various classes of agents. In summary, the overarching rationale of SATURN is to improve methodological standards and conduct research that will help to better understand the impact of antibiotic use on acquisition, selection and transmission of AMR in different environments, by combining analyses of molecular, individual patient-level and ecologic data. The anticipated results may guide clinical and policy decisions to ultimately reduce the burden of AMR in Europe.

Field of science

  • /natural sciences/biological sciences/microbiology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /medical and health sciences/basic medicine/pharmacology and pharmacy

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITE DE GENEVE
Address
Rue Du General Dufour 24
1211 Geneve
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 684 400
Administrative Contact
Stephan Jurgen Harbarth (Dr.)

Participants (15)

STICHTING NIJMEEGS INTERCONFESSIONEEL ZIEKENHUIS CANISIUS WILHELMINA

Participation ended

Netherlands
Address
Weg Door Jonkerbos 100
6532SZ Nijmegen
Activity type
Research Organisations
Administrative Contact
Johan Willem Mouton (Dr.)
UNIVERSYTET MEDYCZNY W LODZI.
Poland
EU contribution
€ 178 761,80
Address
Al. Kosciuszki, 4
90419 Lodz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maciej Godycki-Cwirko (Dr.)
THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV
Israel
EU contribution
€ 922 947
Address
Weizmann Street 6
64239 Tel Aviv
Activity type
Research Organisations
Administrative Contact
Michal Roll (Dr.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 1 017 911
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Ms.)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 592 349,60
Address
Largo Gemelli 1
20123 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 806 190
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne-Marie Laeven (Prof.)
ARTTIC
France
EU contribution
€ 374 041,30
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eric Papon (Dr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 267 567,80
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Ramon Gomis (Prof.)
Fondation hopital Saint Joseph

Participation ended

France
EU contribution
€ 7 451,86
Address
Rue Raymond Losserand 185
75674 Paris
Activity type
Research Organisations
Administrative Contact
Philippe Fradin (Mr.)
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Germany
EU contribution
€ 212 987
Address
Sanderring 2
97070 Wuerzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christian Gloggengiesser (Mr.)
Clinical Center of Serbia
Serbia
EU contribution
€ 145 103,30
Address
Pasterova 2
11000 Belgrade
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Zivan Maksimovic (Dr.)
INSTITUTE FOR INFECTIOUS DISEASES PROF DR. MATEI BALS
Romania
EU contribution
€ 145 975
Address
Street Dr. C. Grozovici 1 1
021105 Bucharest
Activity type
Research Organisations
Administrative Contact
Daniela Dumitrascu (Ms.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 373 549
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johan Willem Mouton (Dr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 235 389,74
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Mr.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 34 811,60
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Evelina Tacconelli (Prof.)