Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases

Project Information

NANOFOL

Grant agreement ID: 228827

Project closed

Start date 1 December 2009

End date 30 November 2013

Funded under

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Total cost € 6 635 409,43

EU contribution € 5 149 874,00

Coordinated by

UNIVERSIDADE DO MINHO
Portugal

Objective

NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.

Fields of science

• medical and health sciences › clinical medicine › rheumatology
• medical and health sciences › health sciences › inflammatory diseases
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis
• engineering and technology › nanotechnology

Programme(s)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Topic(s)

• NMP-2008-4.0-1 - Development of nanotechnology-based systems for diagnosis and/or therapy for diabetes, muscolo-skeletal or inflammatory diseases (in coordination with Theme HEALTH)

Call for proposal

FP7-NMP-2008-LARGE-2
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSIDADE DO MINHO

• EU contribution: € 1 054 530,00
• Address: LARGO DO PACO ; 4704 553 Braga ; Portugal
• Region: Continente › Norte › Cávado
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Vasco Manuel Pinto Texeira (Prof.)
• Total cost: No data

Participants (13)

SUAN FARMA S.A.

Spain

• EU contribution: € 125 572,55
• Address: Einstein 8 ; 28108 Alcobendas
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Ion Arocena Velez (Mr.)
• Total cost: No data

TECHNISCHE UNIVERSITAET GRAZ

Participation ended

Austria

• EU contribution: € 304 036,84
• Address: RECHBAUERSTRASSE 12 ; 8010 Graz
• Region: Südösterreich › Steiermark › Graz
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Georg Guebitz (Prof.)
• Total cost: No data

NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Netherlands

• EU contribution: € 453 858,53
• Address: ANNA VAN BUERENPLEIN 1 ; 2595 DA Den Haag
• Region: West-Nederland › Zuid-Holland › Agglomeratie ’s-Gravenhage
• Activity type: Research Organisations
• Administrative Contact: Herman Lenting (Dr.)
• Total cost: No data

INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC

Portugal

• EU contribution: € 314 437,56
• Address: RUA ALFREDO ALLEN 208 ; 4200 135 Porto
• Region: Continente › Norte › Área Metropolitana do Porto
• Activity type: Research Organisations
• Administrative Contact: Claudia Ferreira (Dr.)
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• EU contribution: € 522 780,00
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Tiphaine Guida (Mrs.)
• Total cost: No data

MEDIZINISCHE UNIVERSITAET WIEN

Austria

• EU contribution: € 452 432,55
• Address: SPITALGASSE 23 ; 1090 Wien
• Region: Ostösterreich › Wien › Wien
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Hannes Stockinger (Prof.)
• Total cost: No data

UNIVERSITATEA AUREL VLAICU DIN ARAD

Romania

• EU contribution: € 285 175,25
• Address: BULEVARD REVOLUTIEI 77 ; 310130 Arad
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ramona Lile (Prof.)
• Total cost: No data

SYNOVO GMBH

Germany

• EU contribution: € 368 373,90
• Address: Paul Ehrlich Str 15 ; 72076 Tuebingen
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Michael Burnet (Dr.)
• Total cost: No data

INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS

France

• EU contribution: € 468 319,00
• Address: PARC TECHNOLOGIQUE ALATA ; 60550 Verneuil En Halatte
• Region: Hauts-de-France › Picardie › Oise
• Activity type: Research Organisations
• Administrative Contact: Lydia Boutigny (Ms.)
• Total cost: No data

EXBIO PRAHA AS

Czechia

• EU contribution: € 418 175,60
• Address: Nad Safinou II, 366 ; 25242 VESTEC
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Stanislav Lancouch
• Total cost: No data

AYMING

France

• EU contribution: € 213 007,00
• Address: RUE CHAPTAL 114 ; 92300 Levallois-Perret
• Region: Ile-de-France › Ile-de-France › Hauts-de-Seine
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Maud Bossard (Ms.)
• Total cost: No data

Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.

Participation ended

Portugal

• EU contribution: € 21 767,53
• Address: Av. da Republica, Quinta do Marques, Estacao Agronomica Nacional IBET/ITQB, Lab.7.14 ; 2780-157 Oeiras
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

UNIVERSITAET FUER BODENKULTUR WIEN

Austria

• EU contribution: € 147 407,69
• Address: GREGOR MENDEL STRASSE 33 ; 1180 Wien
• Region: Ostösterreich › Wien › Wien
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Georg Guebitz (Prof.)
• Total cost: No data