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Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases

Objective

NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.

Call for proposal

FP7-NMP-2008-LARGE-2
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Coordinator

UNIVERSIDADE DO MINHO
Address
Largo Do Paco
4704 553 Braga
Portugal
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 054 530
Administrative Contact
Vasco Manuel Pinto Texeira (Prof.)

Participants (13)

SUAN FARMA S.A.
Spain
EU contribution
€ 125 572,55
Address
Einstein 8
28108 Alcobendas
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ion Arocena Velez (Mr.)
TECHNISCHE UNIVERSITAET GRAZ

Participation ended

Austria
EU contribution
€ 304 036,84
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georg Guebitz (Prof.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 453 858,53
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
Administrative Contact
Herman Lenting (Dr.)
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC
Portugal
EU contribution
€ 314 437,56
Address
Rua Alfredo Allen 208
4200 135 Porto
Activity type
Research Organisations
Administrative Contact
Claudia Ferreira (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 522 780
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Tiphaine Guida (Mrs.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 452 432,55
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hannes Stockinger (Prof.)
UNIVERSITATEA AUREL VLAICU DIN ARAD
Romania
EU contribution
€ 285 175,25
Address
Bulevard Revolutiei 77
310130 Arad
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ramona Lile (Prof.)
SYNOVO GMBH
Germany
EU contribution
€ 368 373,90
Address
Paul Ehrlich Str 15
72076 Tuebingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Burnet (Dr.)
INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
EU contribution
€ 468 319
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations
Administrative Contact
Lydia Boutigny (Ms.)
EXBIO PRAHA AS
Czechia
EU contribution
€ 418 175,60
Address
Nad Safinou Ii 341
25242 Vestec
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stanislav Lancouch
AYMING
France
EU contribution
€ 213 007
Address
Rue Chaptal 114
92300 Levallois-perret
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maud Bossard (Ms.)
Alfama - Investigacao e Desenvolvimento de Produtos Farmaceuticos, Lda.

Participation ended

Portugal
EU contribution
€ 21 767,53
Address
Av. Da Republica, Quinta Do Marques, Estacao Agronomica Nacional Ibet/itqb, Lab.7.14
2780-157 Oeiras
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
UNIVERSITAET FUER BODENKULTUR WIEN
Austria
EU contribution
€ 147 407,69
Address
Gregor Mendel Strasse 33
1180 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georg Guebitz (Prof.)