Objective This project intends to engineer transaminase libraries that will be applied as the main enzymatic technology to deliver the amine functionality in the commercially valuable products of both chiral and bulk amine targets. These enzymes will be used in enzymatic cascades where simple starting materials are converted into the required intermediates for transamination or further enzymatic steps will be used to remove products from the transaminase reaction which will add value by extra functionality. This will also be supported by the development of enzymatic cascades to deliver efficient co-factor recycling and achieve the high conversions required for industrial use. A high throughput screening method based on a further enzymatic cascade will be developed. Engineering solutions will be used to overcome obstacles associated with the implementation of this core technology on a larger scale and integrate the use of other enzymes into the synthetic pathway to allow multi-step, multi-enzyme cascades to be used to deliver complex multi-functional amine products and processes. The industrial partner will target the development of enzymes from the project for specific application into their new products range. Life cycle analysis and environmental impact analysis will compare the final methods with conventional chemical synthesis and allow advantages to be objectively defined. Fields of science engineering and technologyenvironmental engineeringwaste managementwaste treatment processesrecyclingnatural scienceschemical sciencesorganic chemistryaminesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE-2009-3-3-02 - Integrated multi-enzyme, multistep biocatalytic engineering Call for proposal FP7-KBBE-2009-3 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator THE UNIVERSITY OF MANCHESTER EU contribution € 589 350,00 Address OXFORD ROAD M13 9PL Manchester United Kingdom See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Liz Fay (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAET GRAZ Austria EU contribution € 528 240,00 Address UNIVERSITATSPLATZ 3 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Administrative Contact Wolfgang Kroutil (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution € 697 500,00 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact John Woodley (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EVONIK OPERATIONS GMBH Germany EU contribution No data Address RELLINGHAUSER STRASSE 1-11 45128 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Pfeffer (Dr.) Links Contact the organisation Opens in new window Total cost No data RIJKSUNIVERSITEIT GRONINGEN Netherlands EU contribution € 328 192,00 Address Broerstraat 5 9712CP Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact Jan Poutsma (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CLEA TECHNOLOGIES BV Netherlands EU contribution € 256 604,00 Address DELFTECHPARK 34 2628 XH Delft See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ivo Van Der Laan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHIROTECH TECHNOLOGY LIMITED United Kingdom EU contribution € 60 656,00 Address MILTON ROAD 410 Cambridge Science Park - CB4 0PE CAMBRIDGE See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Srinivas Dronamraju (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EVONIK INDUSTRIES AG Germany EU contribution € 64 250,00 Address RELLINGHAUSER STRASSE 1-11 45128 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Administrative Contact Patrick Sittig Links Contact the organisation Opens in new window Website Opens in new window Total cost No data