Skip to main content

AMINE SYNTHESIS THROUGH BIOCATALYTIC CASCADES

Objective

This project intends to engineer transaminase libraries that will be applied as the main enzymatic technology to deliver the amine functionality in the commercially valuable products of both chiral and bulk amine targets. These enzymes will be used in enzymatic cascades where simple starting materials are converted into the required intermediates for transamination or further enzymatic steps will be used to remove products from the transaminase reaction which will add value by extra functionality. This will also be supported by the development of enzymatic cascades to deliver efficient co-factor recycling and achieve the high conversions required for industrial use. A high throughput screening method based on a further enzymatic cascade will be developed. Engineering solutions will be used to overcome obstacles associated with the implementation of this core technology on a larger scale and integrate the use of other enzymes into the synthetic pathway to allow multi-step, multi-enzyme cascades to be used to deliver complex multi-functional amine products and processes. The industrial partner will target the development of enzymes from the project for specific application into their new products range. Life cycle analysis and environmental impact analysis will compare the final methods with conventional chemical synthesis and allow advantages to be objectively defined.

Call for proposal

FP7-KBBE-2009-3
See other projects for this call

Coordinator

THE UNIVERSITY OF MANCHESTER
Address
Oxford Road
M13 9PL Manchester
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 589 350
Administrative Contact
Liz Fay (Ms.)

Participants (7)

UNIVERSITAET GRAZ
Austria
EU contribution
€ 528 240
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wolfgang Kroutil (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 697 500
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
John Woodley (Prof.)
EVONIK OPERATIONS GMBH
Germany
Address
Rellinghauser Strasse 1-11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Pfeffer (Dr.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 328 192
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Poutsma (Dr.)
CLEA TECHNOLOGIES BV
Netherlands
EU contribution
€ 256 604
Address
Delftechpark 34
2628 XH Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivo Van Der Laan (Mr.)
CHIROTECH TECHNOLOGY LIMITED
United Kingdom
EU contribution
€ 60 656
Address
Milton Road 410 Cambridge Science Park -
CB4 0PE Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Srinivas Dronamraju (Mr.)
EVONIK INDUSTRIES AG
Germany
EU contribution
€ 64 250
Address
Rellinghauser Strasse 1-11
45128 Essen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Sittig