Objective Mechanisms of interactions of embryos with their maternal environment are important biological filters limiting reproductive success, both in livestock and the human. Although several aspects of the embryo-maternal interactome have been studied, there is so far no systematic analysis of this biological module. Increasing our knowledge regarding maternal interaction with embryos will lead to creation of novel molecular markers of fertility that will help to improve the fertility of livestock population by genomic selection and thus provide unique competitive advantages to the animal breeding industry. Knowledge of the embryo-maternal interactome will facilitate novel approaches for improving the efficiency and safety of assisted reproduction techniques. Finally, this knowledge has cross-disciplinary applications in human health and is of immense importance for future public health. No systematic studies to date have been performed to allow construction of an in-silico model for the temporal sequence of events involved in maternal communication with embryos. All investigations so far have studied this interaction in isolation, without consideration of spatial or temporal components that may confer consequences for developmental potential. Early embryonic development, implantation and maintenance of pregnancy are critically dependent for intact and efficient communication between embryo and the maternal tract. The overall objective of this application is to identify the local proteomic factors produced in porcine oviduct and uterine horn in response to developing embryo. This information will be used to construct a systemic in-silico based model of oviduct and uterine horn proteomic secretome environment and changes in this milieu, due to embryo development. For this purpose, we evaluate the oviduct secretory proteomic profile alteration in response to embryos at different stage of development. Fields of science medical and health scienceshealth sciencespublic healthsocial sciencessociologydemographyfertilitymedical and health sciencesclinical medicineobstetricsagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandrymedical and health sciencesclinical medicineembryology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development" Call for proposal FP7-PEOPLE-IEF-2008 See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE UNIVERSITY OF SHEFFIELD EU contribution € 172 434,64 Address FIRTH COURT WESTERN BANK S10 2TN Sheffield United Kingdom See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Administrative Contact Justine Daniels (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
