Objective
This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of resistance. The proposal includes development of both slow release and gel formulations, pharmacokinetic and challenge experiments in macaques as well as human studies including a collaborative study with an EDCTP-funded project to use multiplex and proteomic technologies as well as culture-independent DNA-based analysis of mucosal microbiota to investigate biomarkers and establish a baseline signature from which perturbations can be recognised. This is a large consortium comprising 30 partners from 8 EU countries and from Switzerland, Ukraine, South Africa and the United States.Partners include microbicide developers, IPM and Particle Sciences, and producers, Gilead, Tibotec and Virco. Two SMEs will also participate in RTD aspects. The consortium is multidisciplinary with scientists engaged in basic discovery working with new targets and developing novel chemistry to produce compounds with improved safety and efficacy profiles as well as altered patterns of resistance.
Topic(s)
Call for proposal
FP7-HEALTH-2009-single-stage
See other projects for this call
Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
KING'S COLLEGE LONDON
EU contribution
€ 1 203 352,85
Address
STRAND
WC2R 2LS London
United Kingdom
WC2R 2LS London
United Kingdom
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Region
London
Inner London — West
Westminster
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
Participants (33)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 432 200,45
Address
CRANMER TERRACE
SW17 0RE London
SW17 0RE London
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Region
London
Inner London — West
Wandsworth
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 867 938,76
Address
RUE LEBLANC 25
75015 PARIS 15
75015 PARIS 15
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Links
Total cost
No data
INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
EU contribution
€ 694 000,40
Address
NATIONALESTRAAT 155
2000 ANTWERPEN
2000 ANTWERPEN
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Region
Vlaams Gewest
Prov. Antwerpen
Arr. Antwerpen
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 336 000,00
Address
PRINSSTRAAT 13
2000 Antwerpen
2000 Antwerpen
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Region
Vlaams Gewest
Prov. Antwerpen
Arr. Antwerpen
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 299 854,00
Address
UNIVERSITY ROAD LANYON BUILDING
BT7 1NN Belfast
BT7 1NN Belfast
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Region
Northern Ireland
Northern Ireland
Belfast
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 305 000,00
Address
PETERSPLATZ 1
4051 Basel
4051 Basel
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Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 399 679,00
Address
VIA BANCHI DI SOTTO 55
53100 Siena
53100 Siena
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Region
Centro (IT)
Toscana
Siena
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 899 000,00
Address
OUDE MARKT 13
3000 Leuven
3000 Leuven
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Region
Vlaams Gewest
Prov. Vlaams-Brabant
Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
UNIVERSITY COLLEGE LONDON
EU contribution
€ 203 896,80
Address
GOWER STREET
WC1E 6BT LONDON
WC1E 6BT LONDON
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Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
EU contribution
€ 231 548,00
Address
Via Olgettina 60
20132 MILANO
20132 MILANO
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Region
Nord-Ovest
Lombardia
Milano
Activity type
Research Organisations
Links
Total cost
No data
UNIVERSITY OF YORK
United Kingdom
EU contribution
€ 460 689,01
Address
HESLINGTON
YO10 5DD York North Yorkshire
YO10 5DD York North Yorkshire
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Region
Yorkshire and the Humber
North Yorkshire
York
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 299 000,00
Address
HEIDELBERGLAAN 8
3584 CS Utrecht
3584 CS Utrecht
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Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
INSTITUTO DE SALUD CARLOS III
Spain
EU contribution
€ 300 000,00
Address
MONFORTE DE LEMOS 5
28029 Madrid
28029 Madrid
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Region
Comunidad de Madrid
Comunidad de Madrid
Madrid
Activity type
Research Organisations
Links
Total cost
No data
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain
EU contribution
€ 299 000,00
Address
PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
20009 San Sebastian
20009 San Sebastian
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Region
Noreste
País Vasco
Gipuzkoa
Activity type
Research Organisations
Links
Total cost
No data
COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH
South Africa
EU contribution
€ 296 568,00
Address
Meiring Naude Road, Brummeria 46
0001 Pretoria
0001 Pretoria
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Activity type
Research Organisations
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 298 920,00
Address
Piazzale Aldo Moro 5
00185 Roma
00185 Roma
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Region
Centro (IT)
Lazio
Roma
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
Spoluka Chemical Company Ltd
Ukraine
EU contribution
€ 299 000,00
Address
Druzhbi Narodiv 9
01042 Kiev
01042 Kiev
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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data
MINERVA CONSULTING & COMMUNICATION
Belgium
EU contribution
€ 200 560,00
Address
Av. de Tervuren 32-34
1040 BRUSSELS
1040 BRUSSELS
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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest
Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data
STICHTING AMSTERDAM INSTITUTE FOR GLOBAL HEALTH AND DEVELOPMENT
Participation ended
Netherlands
EU contribution
€ 58 048,90
Address
PAASHEUVELWEG 25 TOWER C4
1105 BP Amsterdam
1105 BP Amsterdam
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Activity type
Research Organisations
Links
Total cost
No data
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
EU contribution
€ 109 000,00
Address
DONAUSTRASSE 99
3400 Klosterneuburg
3400 Klosterneuburg
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Region
Ostösterreich
Niederösterreich
Wiener Umland/Nordteil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data
GILEAD SCIENCES INC
United States
EU contribution
No data
Address
LAKESIDE DRIVE 333
94404 Foster City Ca
94404 Foster City Ca
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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data
Particle Sciences Inc.
United States
EU contribution
€ 503 000,00
Address
Courtney Street 3894
18017 Bethlehem
18017 Bethlehem
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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 299 000,00
Address
RUE DU GENERAL DUFOUR 24
1211 Geneve
1211 Geneve
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Region
Schweiz/Suisse/Svizzera
Région lémanique
Genève
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
International Partnership for Microbicides, INC
United States
EU contribution
No data
Address
8401 Colesville Road, Suite 200
20910 Silver Spring
20910 Silver Spring
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Activity type
Research Organisations
Links
Total cost
No data
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 296 360,00
Address
Nobels Vag 5
17177 Stockholm
17177 Stockholm
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Region
Östra Sverige
Stockholm
Stockholms län
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
EUROPEAN AIDS TREATMENT GROUP EV
Germany
EU contribution
€ 33 000,00
Address
LINDEMANNSTRASSE 66
40237 DUSSELDORF
40237 DUSSELDORF
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Region
Nordrhein-Westfalen
Düsseldorf
Düsseldorf, Kreisfreie Stadt
Activity type
Other
Links
Total cost
No data
Fondation Mintaka pour la Recherche Médicale
Switzerland
EU contribution
No data
Address
Chemin des Aulx 14
1228 Plan-Les-Ouates
1228 Plan-Les-Ouates
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Activity type
Research Organisations
Links
Total cost
No data
JANSSEN INFECTIOUS DISEASES DIAGNOSTICS BVBA
Belgium
EU contribution
€ 50 000,00
Address
TURNHOUTSEWEG 30
2340 BEERSE
2340 BEERSE
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Region
Vlaams Gewest
Prov. Antwerpen
Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data
MICROBIOTEC SRL
Italy
EU contribution
€ 198 000,00
Address
VIA DELLE VIGNE 12
53035 Monteriggioni
53035 Monteriggioni
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Region
Centro (IT)
Toscana
Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost
No data
MIDDLESEX UNIVERSITY HIGHER EDUCATION CORPORATION
United Kingdom
EU contribution
€ 300 000,00
Address
THE BURROUGHS, HENDON .
NW4 4BT London
NW4 4BT London
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Region
London
Inner London — West
Camden and City of London
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 417 799,54
Address
SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
SW7 2AZ LONDON
SW7 2AZ LONDON
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Region
London
Inner London — West
Westminster
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 41 950,69
Address
BROWNLOW HILL 765 FOUNDATION BUILDING
L69 7ZX Liverpool
L69 7ZX Liverpool
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Region
North West (England)
Merseyside
Liverpool
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 367 632,00
Address
VIA OLGETTINA 60
20132 Milano
20132 Milano
See on map
Region
Nord-Ovest
Lombardia
Milano
Activity type
Research Organisations
Links
Total cost
No data