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Combined Highly Active Anti-retroviral Microbicides

Objective

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of resistance. The proposal includes development of both slow release and gel formulations, pharmacokinetic and challenge experiments in macaques as well as human studies including a collaborative study with an EDCTP-funded project to use multiplex and proteomic technologies as well as culture-independent DNA-based analysis of mucosal microbiota to investigate biomarkers and establish a baseline signature from which perturbations can be recognised. This is a large consortium comprising 30 partners from 8 EU countries and from Switzerland, Ukraine, South Africa and the United States.Partners include microbicide developers, IPM and Particle Sciences, and producers, Gilead, Tibotec and Virco. Two SMEs will also participate in RTD aspects. The consortium is multidisciplinary with scientists engaged in basic discovery working with new targets and developing novel chemistry to produce compounds with improved safety and efficacy profiles as well as altered patterns of resistance.

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 203 352,85
Administrative Contact
Paul Labbett (Mr.)

Participants (33)

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 432 200,45
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Craven (Dr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 867 938,76
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Etienne Garderet (Mr.)
PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
EU contribution
€ 694 000,40
Address
Nationalestraat 155
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Guido Vanham (Prof.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 336 000
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Ms.)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 299 854
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karl Malcolm (Dr.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 305 000
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephan Grzesiek (Prof.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 399 679
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gianni Pozzi (Prof.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 899 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tina De Greef (Ms.)
University College London
United Kingdom
EU contribution
€ 203 896,80
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
EU contribution
€ 231 548
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Mario Valsecchi (Mr.)
UNIVERSITY OF YORK
United Kingdom
EU contribution
€ 460 689,01
Address
Heslington
YO10 5DD York North Yorkshire
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chris Barber (Mr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 299 000
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mieke Bruin (Ms.)
INSTITUTO DE SALUD CARLOS III
Spain
EU contribution
€ 300 000
Address
Monforte De Lemos 5
28029 Madrid
Activity type
Research Organisations
Administrative Contact
José Alcamí Pertejo (Dr.)
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain
EU contribution
€ 299 000
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Activity type
Research Organisations
Administrative Contact
Alfonso Egaña (Mr.)
COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH
South Africa
EU contribution
€ 296 568
Address
Meiring Naude Road, Brummeria 46
0001 Pretoria
Activity type
Research Organisations
Administrative Contact
Ereck Chakauya (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 298 920
Address
Piazzale Aldo Moro 5
00185 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adele Mannarino (Dr.)
Spoluka Chemical Company Ltd
Ukraine
EU contribution
€ 299 000
Address
Druzhbi Narodiv 9
01042 Kiev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Vasily Pinchuk (Dr.)
MINERVA CONSULTING & COMMUNICATION
Belgium
EU contribution
€ 200 560
Address
Av. De Tervuren 32-34
1040 Brussels
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hinano Spreafico (Ms.)
STICHTING AMSTERDAM INSTITUTE FOR GLOBAL HEALTH AND DEVELOPMENT

Participation ended

Netherlands
EU contribution
€ 58 048,90
Address
Paasheuvelweg 25 Tower C4
1105 BP Amsterdam
Activity type
Research Organisations
Administrative Contact
Friso Janssen (Mr.)
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
EU contribution
€ 109 000
Address
Donaustrasse 99
3400 Klosterneuburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dietmar Katinger (Dr.)
GILEAD SCIENCES INC
United States
Address
Lakeside Drive 333
94404 Foster City Ca
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
James Rooney (Dr.)
Particle Sciences Inc.
United States
EU contribution
€ 503 000
Address
Courtney Street 3894
18017 Bethlehem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Maureen Cochran (Ms.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 299 000
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Oliver Hartley (Prof.)
International Partnership for Microbicides, INC
United States
Address
8401 Colesville Road, Suite 200
20910 Silver Spring
Activity type
Research Organisations
Administrative Contact
Pamela Norick (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 296 360
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Klas Karlsson (Mr.)
EUROPEAN AIDS TREATMENT GROUP EV
Germany
EU contribution
€ 33 000
Address
Mettmanner Strasse 24-26
40233 Dusseldorf
Activity type
Other
Administrative Contact
Hans Ulrich David Haerry (Mr.)
Fondation Mintaka pour la Recherche Médicale
Switzerland
Address
Chemin Des Aulx 14
1228 Plan-les-ouates
Activity type
Research Organisations
Administrative Contact
Robin Offord (Prof.)
JANSSEN INFECTIOUS DISEASES DIAGNOSTICS BVBA
Belgium
EU contribution
€ 50 000
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kristien Bonroy (Dr.)
MICROBIOTEC SRL
Italy
EU contribution
€ 198 000
Address
Via Delle Vigne 12
53035 Monteriggioni
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Caterina Cambiaggi (Dr.)
MIDDLESEX UNIVERSITY HIGHER EDUCATION CORPORATION
United Kingdom
EU contribution
€ 300 000
Address
The Burroughs, Hendon .
NW4 4BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nuria Machin (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 417 799,54
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Ms.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 41 950,69
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
David Mcvey (Mr.)
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 367 632
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi (Dr.)