Combined Highly Active Anti-retroviral Microbicides

Objective

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of resistance. The proposal includes development of both slow release and gel formulations, pharmacokinetic and challenge experiments in macaques as well as human studies including a collaborative study with an EDCTP-funded project to use multiplex and proteomic technologies as well as culture-independent DNA-based analysis of mucosal microbiota to investigate biomarkers and establish a baseline signature from which perturbations can be recognised. This is a large consortium comprising 30 partners from 8 EU countries and from Switzerland, Ukraine, South Africa and the United States.Partners include microbicide developers, IPM and Particle Sciences, and producers, Gilead, Tibotec and Virco. Two SMEs will also participate in RTD aspects. The consortium is multidisciplinary with scientists engaged in basic discovery working with new targets and developing novel chemistry to produce compounds with improved safety and efficacy profiles as well as altered patterns of resistance.

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2009-2.3.2-3 - Discovery and/or development of new and promising anti-HIV microbicides

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

KING'S COLLEGE LONDON

Address

Strand
WC2R 2LS London
United Kingdom

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 203 352,85

Administrative Contact

Paul Labbett (Mr.)

Participants (33)

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom

EU contribution

€ 432 200,45

Address

Cranmer Terrace
SW17 0RE London

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Paul Craven (Dr.)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU contribution

€ 1 867 938,76

Address

Rue Leblanc 25
75015 Paris 15

Activity type

Research Organisations

Administrative Contact

Etienne Garderet (Mr.)

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE

Belgium

EU contribution

€ 694 000,40

Address

Nationalestraat 155
2000 Antwerpen

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Guido Vanham (Prof.)

UNIVERSITEIT ANTWERPEN

Belgium

EU contribution

€ 336 000

Address

Prinsstraat 13
2000 Antwerpen

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Anne Adams (Ms.)

THE QUEEN'S UNIVERSITY OF BELFAST

United Kingdom

EU contribution

€ 299 854

Address

University Road Lanyon Building
BT7 1NN Belfast

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Karl Malcolm (Dr.)

UNIVERSITAT BASEL

Switzerland

EU contribution

€ 305 000

Address

Petersplatz 1
4051 Basel

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Stephan Grzesiek (Prof.)

UNIVERSITA DEGLI STUDI DI SIENA

Italy

EU contribution

€ 399 679

Address

Via Banchi Di Sotto 55
53100 Siena

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Gianni Pozzi (Prof.)

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU contribution

€ 899 000

Address

Oude Markt 13
3000 Leuven

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Tina De Greef (Ms.)

University College London

United Kingdom

EU contribution

€ 203 896,80

Address

Gower Street
WC1E 6BT London

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Greta Borg-Carbott (Ms.)

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

Italy

EU contribution

€ 231 548

Address

Via Olgettina 60
20132 Milano

Activity type

Research Organisations

Administrative Contact

Mario Valsecchi (Mr.)

UNIVERSITY OF YORK

United Kingdom

EU contribution

€ 460 689,01

Address

Heslington
YO10 5DD York North Yorkshire

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Chris Barber (Mr.)

UNIVERSITEIT UTRECHT

Netherlands

EU contribution

€ 299 000

Address

Heidelberglaan 8
3584 CS Utrecht

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Mieke Bruin (Ms.)

INSTITUTO DE SALUD CARLOS III

Spain

EU contribution

€ 300 000

Address

Monforte De Lemos 5
28029 Madrid

Activity type

Research Organisations

Administrative Contact

José Alcamí Pertejo (Dr.)

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE

Spain

EU contribution

€ 299 000

Address

Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian

Activity type

Research Organisations

Administrative Contact

Alfonso Egaña (Mr.)

COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH

South Africa

EU contribution

€ 296 568

Address

Meiring Naude Road, Brummeria 46
0001 Pretoria

Activity type

Research Organisations

Administrative Contact

Ereck Chakauya (Dr.)

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

EU contribution

€ 298 920

Address

Piazzale Aldo Moro 5
00185 Roma

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Adele Mannarino (Dr.)

Spoluka Chemical Company Ltd

Ukraine

EU contribution

€ 299 000

Address

Druzhbi Narodiv 9
01042 Kiev

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

Vasily Pinchuk (Dr.)

MINERVA CONSULTING & COMMUNICATION

Belgium

EU contribution

€ 200 560

Address

Av. De Tervuren 32-34
1040 Brussels

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

Hinano Spreafico (Ms.)

STICHTING AMSTERDAM INSTITUTE FOR GLOBAL HEALTH AND DEVELOPMENT

Participation ended

Netherlands

EU contribution

€ 58 048,90

Address

Paasheuvelweg 25 Tower C4
1105 BP Amsterdam

Activity type

Research Organisations

Administrative Contact

Friso Janssen (Mr.)

POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH

Austria

EU contribution

€ 109 000

Address

Donaustrasse 99
3400 Klosterneuburg

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

Dietmar Katinger (Dr.)

GILEAD SCIENCES INC

United States

Address

Lakeside Drive 333
94404 Foster City Ca

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

James Rooney (Dr.)

Particle Sciences Inc.

United States

EU contribution

€ 503 000

Address

Courtney Street 3894
18017 Bethlehem

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

Maureen Cochran (Ms.)

UNIVERSITE DE GENEVE

Switzerland

EU contribution

€ 299 000

Address

Rue Du General Dufour 24
1211 Geneve

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Oliver Hartley (Prof.)

International Partnership for Microbicides, INC

United States

Address

8401 Colesville Road, Suite 200
20910 Silver Spring

Activity type

Research Organisations

Administrative Contact

Pamela Norick (Ms.)

KAROLINSKA INSTITUTET

Sweden

EU contribution

€ 296 360

Address

Nobels Vag 5
17177 Stockholm

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Klas Karlsson (Mr.)

EUROPEAN AIDS TREATMENT GROUP EV

Germany

EU contribution

€ 33 000

Address

Mettmanner Strasse 24-26
40233 Dusseldorf

Activity type

Other

Administrative Contact

Hans Ulrich David Haerry (Mr.)

Fondation Mintaka pour la Recherche Médicale

Switzerland

Address

Chemin Des Aulx 14
1228 Plan-les-ouates

Activity type

Research Organisations

Administrative Contact

Robin Offord (Prof.)

JANSSEN INFECTIOUS DISEASES DIAGNOSTICS BVBA

Belgium

EU contribution

€ 50 000

Address

Turnhoutseweg 30
2340 Beerse

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

Kristien Bonroy (Dr.)

MICROBIOTEC SRL

Italy

EU contribution

€ 198 000

Address

Via Delle Vigne 12
53035 Monteriggioni

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Administrative Contact

Caterina Cambiaggi (Dr.)

MIDDLESEX UNIVERSITY HIGHER EDUCATION CORPORATION

United Kingdom

EU contribution

€ 300 000

Address

The Burroughs, Hendon .
NW4 4BT London

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Nuria Machin (Ms.)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU contribution

€ 417 799,54

Address

South Kensington Campus Exhibition Road
SW7 2AZ London

Activity type

Higher or Secondary Education Establishments

Administrative Contact

Tatjana Palalic (Ms.)

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU contribution

€ 41 950,69

Address

Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool

Activity type

Higher or Secondary Education Establishments

Administrative Contact

David Mcvey (Mr.)

FONDAZIONE CENTRO SAN RAFFAELE

Italy

EU contribution

€ 367 632

Address

Via Olgettina 60
20132 Milano

Activity type

Research Organisations

Administrative Contact

Maria Rosa Pedrazzi (Dr.)