Objetivo Malaria vaccines are needed to reduce the unacceptably high burden of disease and death in particular in the lowest income countries. Malaria vaccines aim at interruption of the life cycle of the parasite Plasmodium falciparum by induced immune responses in the humans. Transmission-blocking vaccines (TBMV) specifically aim at an arrest sexual stage development preventing the generation of infectious mosquitoes. TBMVs are the most effective tools for reduction of the spread of malaria in the population. This is indispensible for sustained control, elimination and eventually eradication. Pfs48/45 is the most advanced EU-developed malaria TBMV candidate. PF10C is a subunit of Pfs48/45 that has been produced as R0-PF10C in a 20L fermentor. Immunization with 100% properly folded R0-PF10C induced transmission-blocking activity in 100% of immunized mice.Objectives: 1) Manufacture R0-PF10C at cGMP grade and 2) Prepare for clinical trials with R0-PF10C in Africa.Workplan: R0-PF10C production will be optimized and up-scaled for release of clinical grade batches for human trials. To prepare for clinical testing to Africa, preparation for Phase II will be initiated. A Phase II trial of a malaria TB vaccine will require a specific design. Important transmission parameters will be collected and introduced in a mathematical model to study the possible impact on transmission in the selected study area.Milestones: 1) Batch release R0-PF10C for use in clinical trial; 2) Preparation of field site for phase IIb clinical trial with R0-PF10C vaccine Ámbito científico medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesbasic medicineimmunologyimmunisationmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological scienceszoologyinvertebrate zoologynatural sciencesmathematicsapplied mathematicsmathematical model Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH-2009-2.3.2-5 - Translational vaccine research for poverty-related diseases (HIV/AIDS, malaria and/or TB) Convocatoria de propuestas FP7-HEALTH-2009-single-stage Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador STICHTING RADBOUD UNIVERSITEIT Aportación de la UE € 1 151 400,30 Dirección HOUTLAAN 4 6525 XZ Nijmegen Países Bajos Ver en el mapa Región Oost-Nederland Gelderland Arnhem/Nijmegen Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Annemieke Jansens (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo STATENS SERUM INSTITUT Dinamarca Aportación de la UE € 357 600,00 Dirección ARTILLERIVEJ 5 2300 Kobenhavn S Ver en el mapa Región Danmark Hovedstaden Byen København Tipo de actividad Research Organisations Contacto administrativo Michael Scheel Theisen (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Reino Unido Aportación de la UE € 312 424,80 Dirección KEPPEL STREET WC1E 7HT London Ver en el mapa Región London Inner London — West Camden and City of London Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Jana Sabinovska (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos GENNOVA BIOPHARMACEUTICALS LIMITED India Aportación de la UE € 1 026 469,00 Dirección EMCURE HOUSE T 184 MIDC BHOSARI 411026 Pune Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Santoshree Dasgupta (Ms.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos THE GOOD SAMARITAN FOUNDATION Tanzania Aportación de la UE € 37 500,00 Dirección PO BOX 545 - MOSHI Ver en el mapa Tipo de actividad Other Contacto administrativo Gibson Kibiki (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos AFRICAN MALARIA NETWORK TRUST La participación finalizó Tanzania Aportación de la UE € 114 603,90 Dirección RING STREET OFF ROSE GARDEN ROAD 302 33207 DAR ES SALAAM Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Ramadhani Abdallah Noor (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
