Celiac Disease HLA typing using microfabricated genoSENSarray

Project Information

CD-HLASENS

Grant agreement ID: 256395

Project closed

Start date 1 April 2010

End date 31 March 2013

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 45 000,00

EU contribution € 45 000,00

Coordinated by

UNIVERSITAT ROVIRA I VIRGILI
Spain

Objective

Coeliac disease (CD) is a gluten-sensitive enteropathy that affects as much as 1% of the population. Patients with CD should maintain a lifelong gluten-free diet, in order to avoid serious complications. It is essential to diagnose CD at the earliest possible conjecture. The Human Leukocyte Antigen system (HLA) is the human major histocompatibility complex. HLA typing is fundamental in hystocompatibility and previous to solid organ and bone marrow transplantation. In CD, HLA typing can find application in establishing the genetic risk and the association between certain HLA types. The overall objective of CD-HLAsens is therefore to develop a generic technological platform for CD point-of-care diagnostics capable of genomic detection with electrochemical transduction. Genosensors microarrays for the screening of CD disease will be developed based on the detection of nucleic acids associated with genetic predisposition, i.e. HLA typing. Such detection strategy could be used for general population screening but also for neonatal screening. Together with classical assay formats, novel biomolecule detection schemes based on supramolecular associations will be developed with the aim to fine tune the specificity and sensitivity of the sensors. The Researcher will design, new surface chemistry for the functionalisation and operation of the genosensors arrays based on the experiences gained during his previous MC fellowship and new research avenues he has identified (novel sensor surface patterning, electrochemical detection schemes for low resolution HLA typing). In addition, the researcher proposes to continue the successful development of a microfabricated genosensors array, focusing on sensor and microfluidics integration as well as connectivity issues (on chip integration and assay (HLA typing in <15 minutes)). Finally, more emphasise should be brought on the consideration of regulations and commercialisation considera

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences › biological sciences › biochemistry › biomolecules › nucleic acids
• medical and health sciences › health sciences › nutrition
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors
• medical and health sciences › clinical medicine › transplantation
• medical and health sciences › clinical medicine › gastroenterology

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants"

Call for proposal

FP7-PEOPLE-2009-RG
See other projects for this call

Funding Scheme

MC-ERG - European Re-integration Grants (ERG)

Coordinator

UNIVERSITAT ROVIRA I VIRGILI

• EU contribution: € 45 000,00
• Address: CARRER DE ESCORXADOR ; 43003 Tarragona ; Spain
• Region: Este › Cataluña › Tarragona
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data