Objetivo Health care practitioners face daily questions and make choices regarding the effectiveness and quality of several health technologies (e.g. alternative interventions). On this regard they usually consider meta-analysis; the statistical synthesis of results from relevant experiments. The main drawback of the current state of the art is that meta-analysis focuses on comparing only two alternatives. However, clinicians and scientists need to know the relative ranking of a set of alternative options and not only whether option A is better than B. There is an urgent need to establish and disseminate a robust framework for selecting among many treatment options, possibly after taking into account environmental and genetic interactions. The goal of the proposed project is to provide this by establishing and disseminating a revolutionary evidence synthesis toolkit. Its main methodological vehicle is a flexible statistical framework using Bayesian techniques for multiple-treatments meta-analysis. This will enable the relative ranking of all alternative health care options, will allow comprehensive use of all available data, will improve precision and confidence in the conclusions and will answer methodological questions related to bias. Once established in clinical epidemiology, the tool will be extended to genetic epidemiology to account for multiple genetic markers, environmental factors and effects of treatments. Based on ongoing collaborations with teams undertaking applied health care research I plan to evaluate the new tool empirically in real-life health care problems such as ranking the pharmacological treatments for osteoarthritis, indicating the best treatments for multiple sclerosis and ranking the vaccines for influenza. Ámbito científico medical and health scienceshealth sciencespublic healthepidemiologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Convocatoria de propuestas ERC-2010-StG_20091118 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida PANEPISTIMIO IOANNINON Aportación de la UE € 592 500,00 Dirección PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON 45110 Ioannina Grecia Ver en el mapa Región Βόρεια Ελλάδα Ήπειρος Ιωάννινα Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Georgios Detsikas (Mr.) Investigador principal Georgia Salanti (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo PANEPISTIMIO IOANNINON Grecia Aportación de la UE € 592 500,00 Dirección PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON 45110 Ioannina Ver en el mapa Región Βόρεια Ελλάδα Ήπειρος Ιωάννινα Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Georgios Detsikas (Mr.) Investigador principal Georgia Salanti (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
