Objective This grant application is formulated to explore the biological role of the Cullin7 (CUL7) E3 ubiquitin ligase in insulin signaling and its implication for diabetes. My previous work led to the identification of insulin receptor substrate 1 (IRS-1) as the proteolytic target of the CUL7 E3 ligase and uncovered CUL7 as a novel regulator of insulin signaling. Based on these observations, I will employ experimental strategies as outlined in this proposal to delineate CUL7`s role for the cellular insulin response and its contribution to insulin resistance and type 2 diabetes. Fields of science medical and health sciencesclinical medicineendocrinologydiabetes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Call for proposal FP7-PEOPLE-2009-RG See other projects for this call Funding Scheme MC-IRG - International Re-integration Grants (IRG) Coordinator TECHNISCHE UNIVERSITAET MUENCHEN EU contribution € 100 000,00 Address Arcisstrasse 21 80333 Muenchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ulrike Ronchetti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
