Objective
The post-genomic era has been driven by the development of technologies that allow the function of cells and whole organisms to be explored at a molecular level. Metabolomics is concerned with the measurement of global sets of low-molecular-weight metabolites, which represent important indicators of physiological or pathological states of organisms. Such profiles provide a more comprehensive view of cellular control mechanisms in man and animals, and raise the possibility of identifying surrogate markers of disease. Metabolomic approaches use analytical different techniques to measure populations of low-molecular-weight metabolites in biological samples. To decipher large metabolic data sets advanced statistical and bioinformatic tools are commonly employed.
Although metabolomics has only recently emerged, dynamic profiles generated in Metabolic Flux Analysis (MFA) are becoming increasingly important to analyse biological networks in a quantitative manner and as part of systems biology approaches. MFA allows us to probe hypotheses by incorporating a priori biological knowledge to provide practical descriptions of observed cell behaviours, and to characterise the outcome of network perturbations. Flux analysis is of particular value for the diagnosis, differentiation and elucidation of mechanisms in cancer. This was recognised as early as 1924 by the Nobel Prize winner Otto Warburg who attributed cancer to a change in cellular energy production. This theme has experienced a revival in recent years through research, which has established mitochondrial dysfunction as a major mechanism in cancer.
This proposal seeks funding for a truly interdisciplinary European consortium to train researchers to exploit the gains of new technologies provided by metabolic flux analysis in the context of cancer with a mixed focus on new developments and applied end-points.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-ITN
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.