Objective The post-genomic era has been driven by the development of technologies that allow the function of cells and whole organisms to be explored at a molecular level. Metabolomics is concerned with the measurement of global sets of low-molecular-weight metabolites, which represent important indicators of physiological or pathological states of organisms. Such profiles provide a more comprehensive view of cellular control mechanisms in man and animals, and raise the possibility of identifying surrogate markers of disease. Metabolomic approaches use analytical different techniques to measure populations of low-molecular-weight metabolites in biological samples. To decipher large metabolic data sets advanced statistical and bioinformatic tools are commonly employed.Although metabolomics has only recently emerged, dynamic profiles generated in Metabolic Flux Analysis (MFA) are becoming increasingly important to analyse biological networks in a quantitative manner and as part of systems biology approaches. MFA allows us to probe hypotheses by incorporating a priori biological knowledge to provide practical descriptions of observed cell behaviours, and to characterise the outcome of network perturbations. Flux analysis is of particular value for the diagnosis, differentiation and elucidation of mechanisms in cancer. This was recognised as early as 1924 by the Nobel Prize winner Otto Warburg who attributed cancer to a change in cellular energy production. This theme has experienced a revival in recent years through research, which has established mitochondrial dysfunction as a major mechanism in cancer.This proposal seeks funding for a truly interdisciplinary European consortium to train researchers to exploit the gains of new technologies provided by metabolic flux analysis in the context of cancer with a mixed focus on new developments and applied end-points. Fields of science medical and health sciencesclinical medicineoncology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2010-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2010-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator THE UNIVERSITY OF BIRMINGHAM EU contribution € 968 978,92 Address Edgbaston B15 2TT Birmingham United Kingdom See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Administrative Contact May Chung (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 522 998,07 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Keith Cann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 527 681,26 Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT DE BARCELONA Spain EU contribution € 719 028,08 Address GRAN VIA DE LES CORTS CATALANES 585 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Administrative Contact Xavier Gutierrez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 501 045,59 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Rolf Gruetter (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HUN-REN SZEGEDI BIOLOGIAI KUTATOKOZPONT Hungary EU contribution € 453 424,51 Address TEMESVARI KORUT 62 6726 Szeged See on map Region Alföld és Észak Dél-Alföld Csongrád Activity type Research Organisations Administrative Contact Balazs Papp (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEL AVIV UNIVERSITY Participation ended Israel EU contribution No data Address RAMAT AVIV 69978 Tel Aviv See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OXFORD INSTRUMENTS MOLECULAR BIOTOOLS LIMITED United Kingdom EU contribution € 261 672,19 Address Tubney Woods OX13 5QX Abingdon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andrew Sowerby (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOCRATES LIFE SCIENCES AG Austria EU contribution € 429 294,34 Address EDUARD BODEM GASSE 8 1 STOCK 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Julia Schwab (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
