Project description
Virtual Physiological Human
Rupture risk of intracranial aneurysms (IA) has been studied at length. However, very little is known about the healing mechanism, namely the formation of a clot inside the cavity after insertion of a stent. The multiscale interaction between biological and hemodynamic processes is the central ingredient of this proposal. The core of the project is to develop and validate a biological model of spontaneous or stent-induced thrombosis in IA. From this model we will compute quantitative stent efficiency score by its capability to induce clotting in aneurysms. In medical practice the choice of which stent to deploy is left to the medical doctor and remains intuitive to date. It is common to use one or several full-course stents into each other, in order to induce thrombosis formation. Recent Pipieline stents allowing simple or multiple devices constructs with variable flow disruption will be investigated. Our project will study through numerical simulation the effect of stent configuration in patient specific geometry and will help explain why some stents produce good thrombus while others don't. The project will develop a multiscale computational modelling and simulation framework based on the triptych In Vitro - In Vivo - In Silico - rule of three for the thrombosis. The associated technological aim of the project is to deliver software with an interactive end-user interface, providing a virtual simulation of the thrombosis leading to the optimal stent for a specific patient's aneurysm. This goal will be achieved by integrating some of the leading open source software and VPH toolkit software in the area of computational bioengineering. Also a collaborative online system will be adapted allowing partners of THROMBUS to correlate any type of data in case simultaneous multidisciplinary analysis by distant partners is required. This platform will remain operational after the end of the project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences computer and information sciences software
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences mathematics pure mathematics geometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-ICT-2009-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.