Project description Virtual Physiological Human Show the project objective Hide the project objective Rupture risk of intracranial aneurysms (IA) has been studied at length. However, very little is known about the healing mechanism, namely the formation of a clot inside the cavity after insertion of a stent. The multiscale interaction between biological and hemodynamic processes is the central ingredient of this proposal. The core of the project is to develop and validate a biological model of spontaneous or stent-induced thrombosis in IA. From this model we will compute quantitative stent efficiency score by its capability to induce clotting in aneurysms. In medical practice the choice of which stent to deploy is left to the medical doctor and remains intuitive to date. It is common to use one or several full-course stents into each other, in order to induce thrombosis formation. Recent Pipieline stents allowing simple or multiple devices constructs with variable flow disruption will be investigated. Our project will study through numerical simulation the effect of stent configuration in patient specific geometry and will help explain why some stents produce good thrombus while others don't. The project will develop a multiscale computational modelling and simulation framework based on the triptych In Vitro - In Vivo - In Silico - rule of three for the thrombosis. The associated technological aim of the project is to deliver software with an interactive end-user interface, providing a virtual simulation of the thrombosis leading to the optimal stent for a specific patient's aneurysm. This goal will be achieved by integrating some of the leading open source software and VPH toolkit software in the area of computational bioengineering. Also a collaborative online system will be adapted allowing partners of THROMBUS to correlate any type of data in case simultaneous multidisciplinary analysis by distant partners is required. This platform will remain operational after the end of the project. Fields of science natural sciencescomputer and information sciencessoftwaremedical and health sciencesclinical medicineangiologyvascular diseasesnatural sciencesmathematicspure mathematicsgeometry Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2009.5.3 - Virtual Physiological Human Call for proposal FP7-ICT-2009-6 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS EU contribution € 432 538,00 Address RUE MICHEL ANGE 3 75794 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Pascaline TOUTOIS (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE LIBRE DE BRUXELLES Belgium EU contribution € 580 596,00 Address AVENUE FRANKLIN ROOSEVELT 50 1050 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Administrative Contact Christine COURILLON (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 362 752,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Jean-Philippe Thiran (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE GENEVE Switzerland EU contribution € 390 546,00 Address RUE DU GENERAL DUFOUR 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Bastien Chopard (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET SIEGEN Germany EU contribution € 55 000,00 Address ADOLF REICHWEIN STRASSE 2A 57076 Siegen See on map Region Nordrhein-Westfalen Arnsberg Siegen-Wittgenstein Activity type Higher or Secondary Education Establishments Administrative Contact Katja Bieler Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GERMAN RESEARCH SCHOOL FOR SIMULATION SCIENCES GMBH Participation ended Germany EU contribution € 158 502,00 Address STETTERNICHER STAATSFORST 52428 Juelich See on map Activity type Research Organisations Administrative Contact Boris Orth (Dr.) Links Contact the organisation Opens in new window Total cost No data HOSPICES CIVILS DE LYON France EU contribution € 83 783,00 Address QUAI DES CELESTINS 3 69002 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Cecile LEGROS (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COVALIA INTERACTIVE France EU contribution € 276 501,00 Address RUE PROFESSEUR PAUL MILLERET 25000 BESANCON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eric GARCIA (Dr.) Links Contact the organisation Opens in new window Total cost No data EV3 EUROPE SAS France EU contribution € 4 442,00 Address RUE LA BOETIE 75008 PARIS See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jérôme Erath (Mr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 372 000,00 Address SPUI 21 1012WX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Vanessa Wolters (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON France EU contribution € 96 340,00 Address 20 AVENUE ALBERT EINSTEIN 69621 Villeurbanne Cedex See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Françoise MARTIN (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data