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Content archived on 2024-06-18

The interplay between the appetitive dopaminergic and the aversive serotonergic system in motivational control of behavior

Objective

The impact of reward and punishment on behavior is modulated by the neurotransmitters (chemicals that influence signal transfer between neurons) dopamine (DA) and serotonin (5-HT). This project tests a new model of the interplay between DA and 5-HT in motivational control of behavior, by studying the effects of DA and 5-HT increasing drugs on motivational learning and brain activation. Blood oxygen level dependent functional Magnetic Resonance Imaging (BOLD fMRI), a method often used to measure brain activity, is not adequate to assess drug-induced changes in brain activity. In this project new and promising fMRI techniques are used: arterial spin labeling (ASL) and calibrated BOLD fMRI. The results of this project are important for improving methodology in pharmacological fMRI research and may lead to improved treatment for psychiatric patients. The applicant will work for two years (outgoing phase) at the Center for Functional MRI, University of California, San Diego (UCSD), USA. Dr. T. Liu and his colleagues are world leading in the use and development of the abovementioned advanced fMRI techniques. Prof. M. Paulus of the Department of Psychiatry, UCSD, will collaborate on this project. During the return phase, the applicant will work at the Department of Neuropsychology and Psychopharmacology, Maastricht University, The Netherlands, which houses experts in the field of psychopharmacology and toxicology of behavior. This collaboration results in a multidisciplinary research team of experts with excellent training records. The applicant has shown the potential to become a senior researcher. This fellowship will provide the applicant with goal-oriented training, the opportunity to develop complementary skills and to build an international network. The fellowship will make a major contribution to the applicant’s career and to the EU scientific excellence and competitiveness in the field of pharmacological neuroimaging.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2009-IOF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IOF - International Outgoing Fellowships (IOF)

Coordinator

UNIVERSITEIT MAASTRICHT
EU contribution
€ 237 911,80
Address
MINDERBROEDERSBERG 4
6200 MD Maastricht
Netherlands

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Region
Zuid-Nederland Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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