Objective SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3+), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, including a biocompatible PEG layer linked to tumor selective MMP substrate molecules and highly safe and potent novel somatostatin analogue peptides targeting SSTR overexpression. Fields of science medical and health sciencesclinical medicinesurgeryengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensorsmedical and health sciencesclinical medicineradiologynuclear medicineengineering and technologynanotechnologynano-materialsmedical and health sciencesclinical medicineoncologypancreatic cancer Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2010-4.0-1 - Development of nanotechnology-based systems for detection, diagnosis and therapy for cancer Call for proposal FP7-NMP-2010-LARGE-4 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator TEL AVIV UNIVERSITY EU contribution € 842 728,00 Address RAMAT AVIV 69978 Tel Aviv Israel See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lea Pais (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (22) Sort alphabetically Sort by EU Contribution Expand all Collapse all VEREIN ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AM WILHELMINENSPITAL DER STADT WIEN Austria EU contribution € 229 064,00 Address Montleartstrasse 37 1160 WIEN See on map Activity type Research Organisations Administrative Contact Peter Knoll (Prof.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITATSKLINIKUM HEIDELBERG Germany EU contribution € 967 806,00 Address IM NEUENHEIMER FELD 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thorsten Brietz Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BAR ILAN UNIVERSITY Israel EU contribution € 1 123 440,00 Address BAR ILAN UNIVERSITY CAMPUS 52900 Ramat Gan See on map Activity type Higher or Secondary Education Establishments Administrative Contact Billy Mikanovsky (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Italy EU contribution € 461 600,00 Address VIA ZAMBONI 33 40126 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Higher or Secondary Education Establishments Administrative Contact Verdania Bandini (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Germany EU contribution € 252 748,00 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Joerg Kreuter (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RESEARCH AND PRODUCTION COMPLEX NANOSYSTEM LLC Russia EU contribution € 165 200,00 Address 7TH KOZHUKHOVSKAYA 20 115193 MOSKVA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Svetlana Gelperina (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION CIDETEC Spain EU contribution € 553 020,00 Address PASEO MIRAMON 196 PARQUE TECNOLOGICO DE MIRAMON 20014 San Sebastian See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Administrative Contact Iraida Loinaz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Spain EU contribution € 584 000,00 Address PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 20009 San Sebastian See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Administrative Contact Alfonso Egaña (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COLOROBBIA ITALIA SPA Participation ended Italy EU contribution € 56 451,00 Address VIA PIETRAMARINA 53 50059 SOVIGLIANA VINCI See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Poala Terreni (Ms.) Links Contact the organisation Opens in new window Total cost No data MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER Israel EU contribution € 873 865,00 Address TEL HASHOMER SHEBA MEDICAL CENTER 52621 Ramat Gan See on map Activity type Research Organisations Administrative Contact Shlomo Noy (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF EAST ANGLIA United Kingdom EU contribution € 504 200,00 Address EARLHAM ROAD NR4 7TJ Norwich See on map Region East of England East Anglia Norwich and East Norfolk Activity type Higher or Secondary Education Establishments Administrative Contact Alan Walker (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany EU contribution € 630 670,00 Address ISMANINGER STRASSE 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Renate Rädlein Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 470 236,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Elke Lammertyn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 601 107,00 Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY - RUSSIAN ACADEMY OF SCIENCE Russia EU contribution € 560 636,00 Address UL. MIKLUKHO MAKLAYA 16/10 117997 MOSCOW See on map Activity type Higher or Secondary Education Establishments Administrative Contact Sergey Zavriev (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data nHance Technologies Limited Participation ended United Kingdom EU contribution € 359 023,00 Address 5 BRUTON WAY W13 0BY London See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nadipalli Prasad (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FILARETE SERVIZI SRL Italy EU contribution € 356 800,00 Address VIALE ORTLES 22 4 20139 MILANO MI See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Paolo Milani (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GEMS PET SYSTEMS AKTIEBOLAG Participation ended Sweden EU contribution € 40 162,00 Address HUSBYBORG 752 28 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bengt Nielsen (Dr.) Links Contact the organisation Opens in new window Total cost No data OSM-DAN LTD Israel EU contribution € 381 640,00 Address 19 PRO NEEMAN YUVAL ST 7608665 Rehovot See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Pnina Dan (Dr.) Links Contact the organisation Opens in new window Total cost No data BENCAR AB Sweden EU contribution € 338 496,00 Address DAG HAMMARKJOLD VAG 52B 75183 UPPSALA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bengt Långström (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASCEND TECHNOLOGIES LIMITED United Kingdom EU contribution € 133 578,00 Address 15-17 CUMBERLAND PLACE SO15 2BG SOUTHAMPTON See on map Region South East (England) Hampshire and Isle of Wight Southampton Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Victor Popov (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COLOROBBIA CONSULTING SRL Italy EU contribution € 13 530,00 Address VIA PIETRAMARINA 53 50053 Sovigliana See on map Region Centro (IT) Toscana Firenze Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Laura Niccolai (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
