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A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy

Objective

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3+), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, including a biocompatible PEG layer linked to tumor selective MMP substrate molecules and highly safe and potent novel somatostatin analogue peptides targeting SSTR overexpression.

Call for proposal

FP7-NMP-2010-LARGE-4
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Coordinator

TEL AVIV UNIVERSITY
Address
Ramat Aviv
69978 Tel Aviv
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 842 728
Administrative Contact
Lea Pais (Ms.)

Participants (22)

VEREIN ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AM WILHELMINENSPITAL DER STADT WIEN
Austria
EU contribution
€ 229 064
Address
Montleartstrasse 37
1160 Wien
Activity type
Research Organisations
Administrative Contact
Peter Knoll (Prof.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 967 806
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thorsten Brietz
BAR ILAN UNIVERSITY
Israel
EU contribution
€ 1 123 440
Address
Bar Ilan University Campus
52900 Ramat Gan
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Billy Mikanovsky (Ms.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 461 600
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Verdania Bandini (Ms.)
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 252 748
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joerg Kreuter (Prof.)
RESEARCH AND PRODUCTION COMPLEX NANOSYSTEM LLC
Russia
EU contribution
€ 165 200
Address
7Th Kozhukhovskaya 20
115193 Moskva
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Svetlana Gelperina (Dr.)
FUNDACION CIDETEC
Spain
EU contribution
€ 553 020
Address
Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian
Activity type
Research Organisations
Administrative Contact
Iraida Loinaz (Dr.)
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain
EU contribution
€ 584 000
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Activity type
Research Organisations
Administrative Contact
Alfonso Egaña (Mr.)
COLOROBBIA ITALIA SPA

Participation ended

Italy
EU contribution
€ 56 451
Address
Via Pietramarina 53
50059 Sovigliana Vinci
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Poala Terreni (Ms.)
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel
EU contribution
€ 873 865
Address
Tel Hashomer Sheba Medical Center
52621 Ramat Gan
Activity type
Research Organisations
Administrative Contact
Shlomo Noy (Prof.)
UNIVERSITY OF EAST ANGLIA
United Kingdom
EU contribution
€ 504 200
Address
Earlham Road
NR4 7TJ Norwich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alan Walker (Dr.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 630 670
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renate Rädlein
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 470 236
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elke Lammertyn (Dr.)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 601 107
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY - RUSSIAN ACADEMY OF SCIENCE
Russia
EU contribution
€ 560 636
Address
Ul. Miklukho Maklaya 16/10
117997 Moscow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sergey Zavriev (Prof.)
nHance Technologies Limited

Participation ended

United Kingdom
EU contribution
€ 359 023
Address
5 Bruton Way
W13 0BY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nadipalli Prasad (Dr.)
FILARETE SERVIZI SRL
Italy
EU contribution
€ 356 800
Address
Viale Ortles 22/4
20139 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paolo Milani (Prof.)
GEMS PET SYSTEMS AKTIEBOLAG

Participation ended

Sweden
EU contribution
€ 40 162
Address
Husbyborg
752 29 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bengt Nielsen (Dr.)
OSM-DAN LTD
Israel
EU contribution
€ 381 640
Address
19 Pro Neeman Yuval St
7608665 Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pnina Dan (Dr.)
BENCAR AB
Sweden
EU contribution
€ 338 496
Address
Dag Hammarkjold Vag 52B
75183 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bengt Långström (Prof.)
ASCEND TECHNOLOGIES LIMITED
United Kingdom
EU contribution
€ 133 578
Address
2 Venture Road, Southampton Science Park
SO16 7NP Southampton
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Victor Popov (Prof.)
COLOROBBIA CONSULTING SRL
Italy
EU contribution
€ 13 530
Address
Via Pietramarina 53
50053 Sovigliana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laura Niccolai (Dr.)