Objective Effective and long term treatment of cancer is now in sight, but will ultimately require an increasingly ‘personalised’ approach where the ‘right’ combination of drugs will be administered to the ‘right’ patients, based on a detailed understanding of their genetic background and their co-associated sensitivity or resistance ‘biomarkers’. Efforts are specifically required to identify validated risk and patient-response stratification criteria, which can then be used to rationally develop companion diagnostic assays and more stream-lined clinical trials. COLTHERES will address these key issues by:1) Molecularly profiling colon cancer patient samples using multiple ‘omics based technologies for co-segregating lesions that could impart resistance to existing and emerging targeted therapies2) The building and screening of predictive in vitro models based on this data, to enable the rapid and empirical determination of drug resistance biomarkers3) The use of these models and of the clinical studies to prospectively screen for genes mediating resistance and sensitivity to targeted therapies in CRCs4) The building of new algorithms to significantly accelerate the design of rational therapies, by integrating more predictive models, assays and biomarkers into all phases of drug discovery; including novel phase-0 (xenopatients) studies5) The design of innovative and focused biomarker driven phase II trials based on knowledge gathered within the projectCOLTHERES has assembled a unique consortium, from both academia and industrial SMEs, of world- experts in the areas of;• clinical design of innovative biomarker trials and improved therapeutic strategies• ‘omics technologies including genomic, transcriptomic, epigenomic and proteomic profiling• Functional genomic and disease model-generation• Bio-informatics and data analysis, to handle and interrogate the complexity of the data generated through the various approaches Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencesdata sciencenatural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesclinical medicineoncologycolorectal cancer Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.1-8 - Predicting individual response and resistance to cancer therapy. FP7-HEALTH-2010-two-stage Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITA DEGLI STUDI DI TORINO EU contribution € 1 507 200,00 Address VIA GIUSEPPE VERDI 8 10124 Torino Italy See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Alberto Bardelli (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Spain EU contribution € 419 200,00 Address AVENIDA GRAN VIA HOSPITALET 199-203 08908 L'Hospitalet De Llobregat See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Carole Amroune (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Horizon Discovery Limited United Kingdom EU contribution € 920 520,00 Address CAMBRIDGE RESEARCH PARK CB25 9TL Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christopher Torrance (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENDIA NV Netherlands EU contribution € 490 500,00 Address RADARWEG 60 1043 NT AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Iris Simon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 641 200,00 Address PLESMANLAAN 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Rene Bernards (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO) Spain EU contribution € 333 900,00 Address CALLE NAZARET 115-117 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Alejandro Piris Giménez (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA Italy EU contribution € 314 800,00 Address PIAZZA OSPEDALE MAGGIORE 3 20162 MILANO See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Salvatore Siena (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 498 400,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Sofie Heroes (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 348 700,00 Address BROWNLOW HILL 765 FOUNDATION BUILDING L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Jenny Lawson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SIB SWISS INSTITUTE OF BIOINFORMATICS Switzerland EU contribution € 320 880,00 Address RUE MICHEL SERVET 1 CMU 1206 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Research Organisations Administrative Contact Jocelyne Bocquet (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC IN BRUSSELS SPRL Belgium EU contribution € 204 000,00 Address RUE DE LIVOURNE 7 bte 4 1060 BRUXELLES See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Paul Crompton (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data