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Modelling and predicting sensitivity to targeted therapies in colorectal cancers

Objective

Effective and long term treatment of cancer is now in sight, but will ultimately require an increasingly ‘personalised’ approach where the ‘right’ combination of drugs will be administered to the ‘right’ patients, based on a detailed understanding of their genetic background and their co-associated sensitivity or resistance ‘biomarkers’. Efforts are specifically required to identify validated risk and patient-response stratification criteria, which can then be used to rationally develop companion diagnostic assays and more stream-lined clinical trials. COLTHERES will address these key issues by:
1) Molecularly profiling colon cancer patient samples using multiple ‘omics based technologies for co-segregating lesions that could impart resistance to existing and emerging targeted therapies
2) The building and screening of predictive in vitro models based on this data, to enable the rapid and empirical determination of drug resistance biomarkers
3) The use of these models and of the clinical studies to prospectively screen for genes mediating resistance and sensitivity to targeted therapies in CRCs
4) The building of new algorithms to significantly accelerate the design of rational therapies, by integrating more predictive models, assays and biomarkers into all phases of drug discovery; including novel phase-0 (xenopatients) studies
5) The design of innovative and focused biomarker driven phase II trials based on knowledge gathered within the project

COLTHERES has assembled a unique consortium, from both academia and industrial SMEs, of world- experts in the areas of;
• clinical design of innovative biomarker trials and improved therapeutic strategies
• ‘omics technologies including genomic, transcriptomic, epigenomic and proteomic profiling
• Functional genomic and disease model-generation
• Bio-informatics and data analysis, to handle and interrogate the complexity of the data generated through the various approaches

Call for proposal

FP7-HEALTH-2010-two-stage
See other projects for this call

Coordinator

UNIVERSITA DEGLI STUDI DI TORINO
Address
Via Giuseppe Verdi 8
10124 Torino
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 507 200
Administrative Contact
Alberto Bardelli (Prof.)

Participants (10)

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 419 200
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Activity type
Research Organisations
Administrative Contact
Carole Amroune (Ms.)
Horizon Discovery Limited
United Kingdom
EU contribution
€ 920 520
Address
Cambridge Research Park
CB25 9TL Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christopher Torrance (Dr.)
AGENDIA NV
Netherlands
EU contribution
€ 490 500
Address
Radarweg 60
1043 NT Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Iris Simon (Dr.)
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 641 200
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Administrative Contact
Rene Bernards (Prof.)
FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)
Spain
EU contribution
€ 333 900
Address
Calle Nazaret 115-117
08035 Barcelona
Activity type
Research Organisations
Administrative Contact
Alejandro Piris Giménez (Dr.)
AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA
Italy
EU contribution
€ 314 800
Address
Piazza Ospedale Maggiore 3
20162 Milano
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Salvatore Siena (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 498 400
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofie Heroes (Ms.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 348 700
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jenny Lawson (Ms.)
SIB SWISS INSTITUTE OF BIOINFORMATICS
Switzerland
EU contribution
€ 320 880
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
Administrative Contact
Jocelyne Bocquet (Ms.)
ARTTIC IN BRUSSELS SPRL
Belgium
EU contribution
€ 204 000
Address
Rue De Livourne 7 Bte 4
1060 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paul Crompton (Mr.)