Cel The overall objective of this proposal is to capitalise on our expertise in synthetic and fluorine organic chemistry by undertaking a research programme aimed at exploring the value of 18F-labelled N-F reagents. Upon completion of the proposed research programme, we hope to provide 18F-radiochemists with a toolbox filled with novel 18F-radiosynthetic strategies. The unconventional and innovative methods that we will investigate are designed to address well recognised pending problems in 18F-radiolabelling and to offer unprecedented radiosynthetic routes to access 18F-labelled targets. The impact of the novel radiochemistry we propose to develop is far reaching to advance Positron Emission Tomography (PET). PET is a non-invasive molecular imaging technique used clinically for diagnostic purpose and drug discovery. This expanding highly interdisciplinary area of research relies on radiotracers labelled with a positron-emitting radioisotope. 18F-Labelled molecules are frequently used because of the advantageous properties of the 18F in comparison with other non-metallic radioisotopes. For rapid progress, the radiochemistry available for 18F-labelling should be sufficiently diverse for any designed 18F-radiotracers to be accessible regardless of the point of attachment of the 18F-label. To date, this is far from the reality, as current methodologies to construct 18F-labelled molecules present with limitations. The emphasis of this proposal is on the development and use of 18F-labelled N-F reagents of high specific activity for electrophilic fluorination. These reagents should allow for the production of 18F-labelled radiotracers in high radiochemical yield, purity and specific activity. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural scienceschemical sciencesorganic chemistrynatural scienceschemical sciencesnuclear chemistryradiochemistrynatural scienceschemical sciencesinorganic chemistryhalogens Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2010-IIF - Marie Curie Action: "International Incoming Fellowships" Zaproszenie do składania wniosków FP7-PEOPLE-2010-IIF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IIF - International Incoming Fellowships (IIF) Koordynator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Wkład UE € 201 049,60 Adres WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Zjednoczone Królestwo Zobacz na mapie Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Stephen Conway (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
