Objective
A major new frontier in biomedicine is to identify interactions of specific components of nature and nurture in determining risk of complex diseases. Coronary heart disease (CHD) - the single leading cause of death in Europe - is jointly determined by genetic and lifestyle factors. It is unknown, however, how diet, nutrients, and lifestyle factors modulate genetic susceptibility. For scientific and public health reasons, there is a strategic need to study such interactions reliably. There is a unique opportunity for a cost-effective and powerful study because we have:
-conducted detailed assessment of diet and other lifestyle factors in 520K participants in a pan-European prospective study
-identified >12K incident CHD cases accrued during >5M person-years at risk
-identified a random sub-cohort of >15K participants without CHD to serve as referents
-commenced assay of lipid and other markers in 12K cases and 15K referents
-prepared DNA for genetic assay.
In 12K CHD cases and 15K referents, we will assay: >217K genetic variants contained in the state-of-the-art metabochip; 37 fatty acids; and vitamin D metabolites. Analyses will focus on: discovery of interactions; causal evaluation of biomarkers; CHD risk scores.
The findings should open new horizons and contribute towards: 1) explaining missing heritability 2) shaping nutritional guidelines 3) personalising preventive medicine 4) defining approaches to modify genetic susceptibility by avoiding deleterious lifestyles 5) identifying biomarkers that are priority therapeutic targets and 6) innovative prognostic tools.
Gene-lifestyle interplay is a major future growth area. This world-leading study will enhance Europes strengths in public health, nutrition and genetic epidemiology, and create a valuable future resource.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences public health epidemiology
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences health sciences nutrition
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-AdG_20100317
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
CB2 1TN Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.