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Interplay of genetic, nutrient and lifestyle factors on incidence of coronary disease: EPIC-Heart

Objective

A major new frontier in biomedicine is to identify interactions of specific components of nature and nurture in determining risk of complex diseases. Coronary heart disease (CHD) - the single leading cause of death in Europe - is jointly determined by genetic and lifestyle factors. It is unknown, however, how diet, nutrients, and lifestyle factors modulate genetic susceptibility. For scientific and public health reasons, there is a strategic need to study such interactions reliably. There is a unique opportunity for a cost-effective and powerful study because we have:
-conducted detailed assessment of diet and other lifestyle factors in 520K participants in a pan-European prospective study
-identified >12K incident CHD cases accrued during >5M person-years at risk
-identified a random sub-cohort of >15K participants without CHD to serve as referents
-commenced assay of lipid and other markers in 12K cases and 15K referents
-prepared DNA for genetic assay.
In 12K CHD cases and 15K referents, we will assay: >217K genetic variants contained in the state-of-the-art metabochip; 37 fatty acids; and vitamin D metabolites. Analyses will focus on: discovery of interactions; causal evaluation of biomarkers; CHD risk scores.
The findings should open new horizons and contribute towards: 1) explaining missing heritability 2) shaping nutritional guidelines 3) personalising preventive medicine 4) defining approaches to modify genetic susceptibility by avoiding deleterious lifestyles 5) identifying biomarkers that are priority therapeutic targets and 6) innovative prognostic tools.
Gene-lifestyle interplay is a major future growth area. This world-leading study will enhance Europes strengths in public health, nutrition and genetic epidemiology, and create a valuable future resource.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/health sciences/nutrition
  • /natural sciences/biological sciences/biochemistry/biomolecules/lipids

Call for proposal

ERC-2010-AdG_20100317
See other projects for this call

Funding Scheme

ERC-AG - ERC Advanced Grant

Host institution

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 901 175,29
Principal investigator
John Navid Danesh (Prof.)
Administrative Contact
Renata Schaeffer (Ms.)

Beneficiaries (3)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 1 901 175,29
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Principal investigator
John Navid Danesh (Prof.)
Administrative Contact
Renata Schaeffer (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 427 676,89
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Albert Koulman (Dr.)
VITAS AS
Norway
EU contribution
€ 170 302,22
Address
Gaustadalleen 21
0349 Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marit Markhus (Ms.)