Cel Translational research for human health on major diseases such as cancer, cardiovascular disease, diabetes and obesity requires modalities that can monitor an ever widening spectrum of physiological signals over extended periods of time in animal models unhindered by anaesthesia or restraint. We hypothesize that a novel generation of in vivo rechargeable, telemetry-based electrochemical sensors will facilitate continuous recording of a hitherto uncharted spectrum of signals in different tissues and thereby will hugely improve testing and validation of new drugs as well as our understanding of physiology and pathophysiology.Elucidating the link between renal oxygenation and kidney health, will have major impact in the clinical practice, making it a very promising and timely subject. To allow such a breakthrough this proposal will start with the realisation of a telemetry-based solution for chronic measurement of oxygen in the kidney.This inherently multidisciplinary project will partner with the University of Auckland, a leading site in biomedical engineering, for the development and testing of novel telemetry devices. In acute experiments surgical methods and hardware will be refined and tested before progressing to experiments in conscious animals. Thereafter renal oxygen will be continuously recorded in an accepted rat model of chronic kidney disease without and with therapy to confirm disturbed oxygen homeostasis and to evaluate treatment efficacy.This fellowship will not only generate groundbreaking technology, knowledge and expertise to study kidney oxygenation, but it will also allow me to be at the forefront of a new area in physiology research. On my return to the home institute we will be able force breakthroughs within the European Research Area for mechanistic studies on hypoxia-dependent progression of kidney disease. Dziedzina nauki medical and health sciencesmedical biotechnologymedical and health sciencesclinical medicinecardiologycardiovascular diseasesengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsmedical and health sciencesclinical medicineanaesthesiologymedical and health sciencesclinical medicinenephrologykidney diseases Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2010-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Zaproszenie do składania wniosków FP7-PEOPLE-2010-IOF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IOF - International Outgoing Fellowships (IOF) Koordynator UNIVERSITAIR MEDISCH CENTRUM UTRECHT Wkład UE € 238 119,20 Adres HEIDELBERGLAAN 100 3584 CX Utrecht Niderlandy Zobacz na mapie Region West-Nederland Utrecht Utrecht Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Jaap A. Joles (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
