Objective Metagenomes comprise enormous reservoirs coding for proteins with useful activities. Unfortunately, harvesting this reservoir is difficult, because useful candidates are rare and hidden in an overwhelming majority of irrelevant genes. Screening campaigns of metagenomic libraries thus require massive capital-expenditure for robotic systems and much manpower, making them expensive, slow and available to very few users. To enable valorisation of the potential of the metagenome, this project assembles an interdisciplinary and intersectoral consortium that will integrate a range of technologies into a platform designed to beat the odds of identifying library hits faster, more efficiently and by a wider user base. Exploration and exploitation of the metagenome will be made faster and more successful by (i) ultrahigh-throughput screening in picoliter droplets that dramatically lowers the cost per assay to well below 0.01 cents and allows throughput of 10e7 assays per hour; (ii) workflows that streamline and increase the yield of library construction and functional expression and (iii) workflows for efficient bioinformatic analysis of hits based on user-friendly software solutions for metagenome analysis. Emphasis is put on technologies that are straightforwardly implemented in non-specialist labs, maximising the impact of METAFLUIDICS. This platform will be used to identify enzymes for biosynthesis of therapeutic small molecules, for green bioenergy conversion, bioremediation, food chemistry and other industrial applications Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencescomputer and information sciencessoftwareengineering and technologyenvironmental biotechnologybioremediationnatural sciencesbiological sciencesmicrobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) H2020-EU.2.1.4. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology Main Programme Topic(s) BIOTEC-6-2015 - Metagenomics as innovation driver Call for proposal H2020-BIOTEC-2014-2015 See other projects for this call Sub call H2020-LEIT-BIO-2015-1 Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSIDAD AUTONOMA DE MADRID Net EU contribution € 1 233 729,00 Address CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO 28049 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 233 729,00 Participants (15) Sort alphabetically Sort by Net EU contribution Expand all Collapse all QIAGEN AARHUS AS Denmark Net EU contribution € 463 750,00 Address SILKEBORGVEJ 2 8000 Aarhus See on map Region Danmark Midtjylland Østjylland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 463 750,00 BIOILIBERIS RESEARCH AND DEVELOPMENT SL Spain Net EU contribution € 460 000,00 Address AV DE LA INNOVACION 1 PARQUE TECNOLOGICO DE CIENCIAS SALUD 18100 ARMILLA GRANADA See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Sur Andalucía Granada Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 460 000,00 DROP-TECH LTD United Kingdom Net EU contribution € 207 820,00 Address Canterbury Street, Canterbury Court 91 CB4 3QU Cambridge See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 207 820,00 PROZOMIX LIMITED United Kingdom Net EU contribution € 546 806,25 Address STATION COURT 3 NE49 9HN Haltwhistle See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region North East (England) Northumberland and Tyne and Wear Northumberland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 546 806,25 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom Net EU contribution € 1 120 190,00 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 120 190,00 NOVOZYMES A/S Denmark Net EU contribution € 821 729,00 Address Krogshoejvej 36 2880 Bagsvaerd See on map Region Danmark Hovedstaden Københavns omegn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 821 729,00 INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE France Net EU contribution € 521 130,00 Address AVENUE DE RANGUEIL 135 31077 TOULOUSE CEDEX 4 See on map Region Occitanie Midi-Pyrénées Haute-Garonne Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 722 255,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France Net EU contribution € 201 125,00 Address 147 RUE DE L'UNIVERSITE 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 201 125,00 CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO Portugal Net EU contribution € 407 590,00 Address UNIVERSIDADE DE COIMBRA LARGO MARQUES DE POMBAL 3004 517 Coimbra See on map Region Continente Centro (PT) Região de Coimbra Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 407 590,00 UNIVERSIDAD DE ALICANTE Spain Net EU contribution € 595 600,00 Address CAMPUS DE SAN VICENTE RASPEIG 03690 Alicante See on map Region Este Comunitat Valenciana Alicante/Alacant Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 595 600,00 AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain Net EU contribution € 581 665,70 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 636 282,50 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. INSTITUTO NACIONAL DE TECNICA AEROESPACIAL ESTEBAN TERRADAS Spain Net EU contribution € 54 616,80 Address CR TORREJON AJALVIR KM 4 2 28850 Torrejon De Ardoz Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 54 616,80 NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Norway Net EU contribution € 840 357,50 Address HOGSKOLERINGEN 1 7491 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 840 357,50 STIFTELSEN SINTEF Participation ended Norway Net EU contribution € 291 006,41 Address STRINDVEIEN 4 7034 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 291 006,41 SINTEF AS Norway Net EU contribution € 461 247,34 Address STRINDVEGEN 4 7034 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 461 247,34