Project description
Investigating neuronal communication for therapeutic innovation
Neurons form intricate networks and communicate with each other through synaptic protein complexes. Neuronal excitability and signal propagation are governed by transcriptional and post-transcriptional regulation of gene expression as well as by precise protein trafficking. With the support of the Marie Skłodowska-Curie Actions programme, the NERVSPAN project aims to investigate neuronal function and identify biomarkers that distinguish healthy from pathological neuronal states. By training young researchers in techniques such as RNA sequencing, proteomics and optogenetics, the project will prepare fellows for careers in neurobiology and pave the way towards drug discovery and therapy development.
Objective
The objective of this network is to train, through research, a group of 10 young scientists, giving them the practical skills and knowledge necessary to tackleThe function of a neuron is determined by its expression of morphogen receptors and adhesion proteins (to pattern its connectome), of synaptic protein complexes (for intercellular communication), and of ion channels (for neuronal excitability and signal propagation). The protein composition of any neuron is itself dependent on gene expression controlled by transcription factors and by post-transcriptional regulations (splicing, translation, protein stability). Finally, neurons are highly compartmentalized cells and require trafficking of proteins to their correct locations. Alterations of these neuronal features can therefore be observed at multiple levels: molecular, cellular, and behavioral. We will focus on three neuronal features: i) gene expression levels as measured by RNA sequencing and proteomics, ii) assembly of functional multiprotein complexes (by high resolution microscopy and proximity dependent protein labelling), and iii) phenotypic output via a combination of optogenetics, calcium imaging, and behavioral assays.
This research program will help define the critical features that differentiate between physiological and pathological states of a given neuron. Such biomarkers would be precious to facilitate drug screens or develop novel therapeutic strategies for human neurological diseases.
The interdisciplinary research and training programme will cover a broad spectrum of approaches and topics, from
intracellular molecular interactions to cellcell communication, gene expression profiling, the impact of deleterious mutations,
behavioral studies, and translation regulation. Coupled with extensive network-wide transferable skills training, this will prepare the
fellows for careers in the medically important field of neurobiology as well as a broad range of carriers including government and
industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.