Objective
The objective of this network is to train, through research, a group of 10 young scientists, giving them the practical skills and knowledge necessary to tackleThe function of a neuron is determined by its expression of morphogen receptors and adhesion proteins (to pattern its connectome), of synaptic protein complexes (for intercellular communication), and of ion channels (for neuronal excitability and signal propagation). The protein composition of any neuron is itself dependent on gene expression controlled by transcription factors and by post-transcriptional regulations (splicing, translation, protein stability). Finally, neurons are highly compartmentalized cells and require trafficking of proteins to their correct locations. Alterations of these neuronal features can therefore be observed at multiple levels: molecular, cellular, and behavioral. We will focus on three neuronal features: i) gene expression levels as measured by RNA sequencing and proteomics, ii) assembly of functional multiprotein complexes (by high resolution microscopy and proximity dependent protein labelling), and iii) phenotypic output via a combination of optogenetics, calcium imaging, and behavioral assays.
This research program will help define the critical features that differentiate between physiological and pathological states of a given neuron. Such biomarkers would be precious to facilitate drug screens or develop novel therapeutic strategies for human neurological diseases.
The interdisciplinary research and training programme will cover a broad spectrum of approaches and topics, from
intracellular molecular interactions to cell–cell communication, gene expression profiling, the impact of deleterious mutations,
behavioral studies, and translation regulation. Coupled with extensive network-wide transferable skills training, this will prepare the
fellows for careers in the medically important field of neurobiology as well as a broad range of carriers including government and
industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesneurobiology
- social sciencespsychologybehavioural psychology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural scienceschemical sciencesinorganic chemistryalkaline earth metals
- natural sciencesbiological sciencesgeneticsRNA
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Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
75654 Paris
France
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Participants (7)
69622 Villeurbanne Cedex
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67404 Illkirch Graffenstaden
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7610001 Rehovot
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3584 CS Utrecht
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1050 Bruxelles / Brussel
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3400 Klosterneuburg
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Participation ended
3584 CT Utrecht
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (10)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
CB1 1EE Cambridge
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
97453 Schonungen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
LN10 6TP Woodhall Spa
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3015 LD Netherlands
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1080 Wien
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
33000 Bordeaux
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
DH1 3LE Durham
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
67081 Strasbourg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
TS21 3FD Sedgefield
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