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Radically New Cancer Therapy Based on Advances in Nanotechnology and Photonics for Simultaneous Imaging and Treatment of Solid Tumours

Project description

Advanced cancer imaging and treatment

Radiotherapy constitutes a significant tool in the fight against cancer. However, conventional radiotherapy often involves high radiation doses, which can lead to significant side effects and harm healthy tissues. To overcome this limitation, the EIC-funded ScanNanoTreat project is developing a transformative theranostic approach that combines advanced photonics, nanotechnology and K-edge imaging. This innovative system enables simultaneous imaging and treatment of solid tumours such as breast and pancreatic cancers. Low-energy X-rays from Spectral Photon Counting CT and optimised nanoprobes can reduce radiation doses by over 30 % compared to traditional methods. By improving precision and minimising radiation exposure time, ScanNanoTreat could significantly enhance treatment outcomes, reduce side effects and lower cancer care costs.

Objective

Cancer treatment is a significant healthcare challenge, costing Europe up to €199 billion annually. The burden will grow substantially, with a projected 60% increase in cancer cases from 2018 to 2040. To address these challenges, the ScanNanoTreat consortium consisting of Claude Bernard Lyon 1 University, Maastricht University, Guerbet, Philips, and Inlecom Commercial Pathways is developing a revolutionary theranostic approach combining advanced photonics and nanotechnology.
The innovative system integrates Spectral Photon Counting Computed Tomography (SPCCT) with X-ray-activated Photodynamic Therapy (X-PDT) using gadolinium-based nanoprobes. This approach enables simultaneous imaging and treatment of solid tumours, with an initial focus on breast and pancreatic cancers.
By leveraging low-energy X-rays and optimized nanoprobes, ScanNanoTreat aims to reduce radiation doses by over 30% compared to conventional radiotherapy. This technology is expected to radically shorten the diagnosis-treatment cycle, leading to improved prognosis and better patient outcomes, and up to 40% reduction in cancer treatment costs. If successfully deployed, ScanNanoTreat could revolutionize the European theranostic market, aiming to capture 10-17% of the projected €493 million market by 2032, suggesting a potential market size of €35-€60 million by 2035. The project will advance the technology from TRL 3 to TRL 5, preparing for clinical trials by 2027 and potential market entry by 2035. Additionally, a business plan and exploitation strategy will be developed, targeting a spinoff creation to commercialize the technology. The support of the EIC Transition grant is crucial to conduct preclinical studies, optimize the SPCCT system, and develop a comprehensive regulatory strategy.
By addressing critical healthcare needs and aligning with EU strategic autonomy in MedTech, ScanNanoTreat will radically improve cancer care and contribute to the sustainability of European healthcare systems.

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HORIZON-EIC - HORIZON EIC Grants

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Call for proposal

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(opens in new window) HORIZON-EIC-2024-TRANSITION-01

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Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 654 525,00
Address
BOULEVARD DU 11 NOVEMBRE 1918 NUM43
69622 Villeurbanne Cedex
France

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (5)

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