Project description
Advanced cancer imaging and treatment
Radiotherapy constitutes a significant tool in the fight against cancer. However, conventional radiotherapy often involves high radiation doses, which can lead to significant side effects and harm healthy tissues. To overcome this limitation, the EIC-funded ScanNanoTreat project is developing a transformative theranostic approach that combines advanced photonics, nanotechnology and K-edge imaging. This innovative system enables simultaneous imaging and treatment of solid tumours such as breast and pancreatic cancers. Low-energy X-rays from Spectral Photon Counting CT and optimised nanoprobes can reduce radiation doses by over 30 % compared to traditional methods. By improving precision and minimising radiation exposure time, ScanNanoTreat could significantly enhance treatment outcomes, reduce side effects and lower cancer care costs.
Objective
Cancer treatment is a significant healthcare challenge, costing Europe up to €199 billion annually. The burden will grow substantially, with a projected 60% increase in cancer cases from 2018 to 2040. To address these challenges, the ScanNanoTreat consortium consisting of Claude Bernard Lyon 1 University, Maastricht University, Guerbet, Philips, and Inlecom Commercial Pathways is developing a revolutionary theranostic approach combining advanced photonics and nanotechnology.
The innovative system integrates Spectral Photon Counting Computed Tomography (SPCCT) with X-ray-activated Photodynamic Therapy (X-PDT) using gadolinium-based nanoprobes. This approach enables simultaneous imaging and treatment of solid tumours, with an initial focus on breast and pancreatic cancers.
By leveraging low-energy X-rays and optimized nanoprobes, ScanNanoTreat aims to reduce radiation doses by over 30% compared to conventional radiotherapy. This technology is expected to radically shorten the diagnosis-treatment cycle, leading to improved prognosis and better patient outcomes, and up to 40% reduction in cancer treatment costs. If successfully deployed, ScanNanoTreat could revolutionize the European theranostic market, aiming to capture 10-17% of the projected €493 million market by 2032, suggesting a potential market size of €35-€60 million by 2035. The project will advance the technology from TRL 3 to TRL 5, preparing for clinical trials by 2027 and potential market entry by 2035. Additionally, a business plan and exploitation strategy will be developed, targeting a spinoff creation to commercialize the technology. The support of the EIC Transition grant is crucial to conduct preclinical studies, optimize the SPCCT system, and develop a comprehensive regulatory strategy.
By addressing critical healthcare needs and aligning with EU strategic autonomy in MedTech, ScanNanoTreat will radically improve cancer care and contribute to the sustainability of European healthcare systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology nanotechnology
- medical and health sciences clinical medicine oncology pancreatic cancer
- natural sciences physical sciences theoretical physics particle physics photons
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2024-TRANSITION-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69622 Villeurbanne Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.