Objective The proposal aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Established diagnostic imaging modalities (e.g. X-ray Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography) provide 3D anatomical, functional or pathological information with spatial resolution in the millimetre range. However, these methods cannot be applied continuously or at the bedside. Diffuse optical imaging is expected to provide a valuable complementing tool to assess perfusion and blood oxygenation in brain tissue and their time evolution in a continuous or quasi-continuous manner. The devices will be portable and comparably inexpensive and can be applied in adults and in children. Time-domain techniques are acknowledged as offering superior information content and sensitivity compared to other optical methods, allowing for separation between contributions of surface tissues (skin and skull) and brain tissue. Time-domain imaging can also differentiate between the effects of scatter and those of absorption.The consortium plans major developments in technology and data analysis that will enhance time-domain diffuse optical imaging with respect to spatial resolution, sensitivity, robustness of quantification as well as performance of related instruments in clinical diagnosis and monitoring. The diagnostic value of time-domain diffuse optical imaging will be assessed by clinical pilot studies addressing specific neurological disorders, in comparison with established neurophysiological and neuroimaging techniques. Perspectives regarding clinical application of time-domain diffuse optical brain imaging will be estimated and a reliable basis for a potential commercialisation of this novel technique by European system manufacturers will be created. Fields of science natural sciencescomputer and information sciencesdata sciencemedical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesbasic medicineneurologystrokeengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Keywords Diffuse optical imaging brain imaging epilepsy near-infrared spectroscopy stroke time-domain Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.2-2 - Novel optical methodologies for detection, diagnosis and monitoring of disease or disease-related processes Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator POLITECNICO DI MILANO EU contribution € 1 120 222,00 Address PIAZZA LEONARDO DA VINCI 32 20133 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Rinaldo Cubeddu (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all PHYSIKALISCH-TECHNISCHE BUNDESANSTALT Germany EU contribution € 735 420,00 Address BUNDESALLEE 100 38116 Braunschweig See on map Region Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Maren Jachmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 827 715,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kent Lee (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTYTUT BIOCYBERNETYKI I INZYNIERII BIOMEDYCZNEJ IM.MACIEJA NALECZA POLSKIEJ AKADEMII NAUK Poland EU contribution € 490 480,00 Address UL. KSIECIA TROJDENA 4 02 109 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Higher or Secondary Education Establishments Administrative Contact Elzbieta Zachara (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA Italy EU contribution € 279 999,00 Address VIA GIOVANNI CELORIA 11 20133 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Alessandro Moneta (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 360 000,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräßdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WARSZAWSKI UNIWERSYTET MEDYCZNY Poland EU contribution € 113 100,00 Address UL. ZWIRKI I WIGURY 61 02 091 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Higher or Secondary Education Establishments Administrative Contact Michal Skrzek (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT FUR LASERTECHNOLOGIEN IN DER MEDIZIN UND MESSTECHNIK AN DER U NIVERSITAT ULM Germany EU contribution € 300 000,00 Address Helmholzstrasse 12 89081 ULM See on map Activity type Research Organisations Administrative Contact Peter Spiertz (Mr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI FIRENZE Italy EU contribution € 250 392,00 Address Piazza San Marco 4 50121 Florence See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Administrative Contact Daniele Dominici (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF BATH United Kingdom EU contribution € 169 386,00 Address CLAVERTON DOWN BA2 7AY Bath See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire Activity type Higher or Secondary Education Establishments Administrative Contact Peter Hompstead (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FIANIUM LTD United Kingdom EU contribution € 220 320,00 Address COMPASS POINT 20 ENSIGN WAY HAMBLE S031 4RA Southampton See on map Region South East (England) Hampshire and Isle of Wight Southampton Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact John Clowes (Dr.) Links Contact the organisation Opens in new window Total cost No data MICRO PHOTON DEVICES SRL Italy EU contribution € 319 500,00 Address VIA WALTRAUD GEBERT DEEG 3/F 39100 Bolzano See on map Region Nord-Est Provincia Autonoma di Bolzano/Bozen Bolzano-Bozen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Roberto Biasi (Dr.) Links Contact the organisation Opens in new window Total cost No data BECKER & HICKL GMBH Germany EU contribution € 386 119,00 Address NAHMITZER DAMM 30 12277 BERLIN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Helmut Hickl (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL Italy EU contribution € 166 000,00 Address Via Giuseppe Mussi 1 20154 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Carla Finocchiaro (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data