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Non-invasive imaging of brain function and disease by pulsed near infrared light

Objective

The proposal aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Established diagnostic imaging modalities (e.g. X-ray Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography) provide 3D anatomical, functional or pathological information with spatial resolution in the millimetre range. However, these methods cannot be applied continuously or at the bedside. Diffuse optical imaging is expected to provide a valuable complementing tool to assess perfusion and blood oxygenation in brain tissue and their time evolution in a continuous or quasi-continuous manner. The devices will be portable and comparably inexpensive and can be applied in adults and in children. Time-domain techniques are acknowledged as offering superior information content and sensitivity compared to other optical methods, allowing for separation between contributions of surface tissues (skin and skull) and brain tissue. Time-domain imaging can also differentiate between the effects of scatter and those of absorption.The consortium plans major developments in technology and data analysis that will enhance time-domain diffuse optical imaging with respect to spatial resolution, sensitivity, robustness of quantification as well as performance of related instruments in clinical diagnosis and monitoring. The diagnostic value of time-domain diffuse optical imaging will be assessed by clinical pilot studies addressing specific neurological disorders, in comparison with established neurophysiological and neuroimaging techniques. Perspectives regarding clinical application of time-domain diffuse optical brain imaging will be estimated and a reliable basis for a potential commercialisation of this novel technique by European system manufacturers will be created.

Call for proposal

FP7-HEALTH-2007-A
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

POLITECNICO DI MILANO
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 120 222
Administrative Contact
Rinaldo Cubeddu (Prof.)

Participants (13)

PHYSIKALISCH-TECHNISCHE BUNDESANSTALT
Germany
EU contribution
€ 735 420
Address
Bundesallee 100
38116 Braunschweig
Activity type
Research Organisations
Administrative Contact
Maren Jachmann (Ms.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 827 715
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kent Lee (Mr.)
INSTYTUT BIOCYBERNETYKI I INZYNIERII BIOMEDYCZNEJ IM.MACIEJA NALECZA POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 490 480
Address
Ul. Ksiecia Trojdena 4
02 109 Warszawa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elzbieta Zachara (Ms.)
FONDAZIONE IRCCS ISTITUTO NEUROLOGICO CARLO BESTA
Italy
EU contribution
€ 279 999
Address
Via Giovanni Celoria 11
20133 Milano
Activity type
Research Organisations
Administrative Contact
Alessandro Moneta (Mr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 360 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)
WARSZAWSKI UNIWERSYTET MEDYCZNY
Poland
EU contribution
€ 113 100
Address
Ul. Zwirki I Wigury 61
02 091 Warszawa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michal Skrzek (Mr.)
INSTITUT FUR LASERTECHNOLOGIEN IN DER MEDIZIN UND MESSTECHNIK AN DER U NIVERSITAT ULM
Germany
EU contribution
€ 300 000
Address
Helmholzstrasse 12
89081 Ulm
Activity type
Research Organisations
Administrative Contact
Peter Spiertz (Mr.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 250 392
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniele Dominici (Prof.)
UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 169 386
Address
Claverton Down
BA2 7AY Bath
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hompstead (Mr.)
FIANIUM LTD
United Kingdom
EU contribution
€ 220 320
Address
Compass Point 20 Ensign Way Hamble
S031 4RA Southampton
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
John Clowes (Dr.)
MICRO PHOTON DEVICES SRL
Italy
EU contribution
€ 319 500
Address
Via Waltraud Gebert Deeg 3/F
39100 Bolzano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberto Biasi (Dr.)
BECKER & HICKL GMBH
Germany
EU contribution
€ 386 119
Address
Nahmitzer Damm 30
12277 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Helmut Hickl (Mr.)
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italy
EU contribution
€ 166 000
Address
Via Giuseppe Mussi 1
20154 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carla Finocchiaro (Ms.)