Objective Despite major efforts, identifying susceptibility genes for common human diseases - cancer, cardiovascular, inflammatory and neurological disorders - is difficult due to the complexity of the underlying causes. The dog population is composed of ~ 400 purebred breeds; each one is a genetic isolate with unique characteristics resulting from persistent selection for desired attributes or from genetic drift / inbreeding. Dogs tend to suffer from the same range of diseases than human but the genetic complexity of these diseases within a breed is reduced as a consequence of the genetic drift and – due to long-range linkage disequilibrium – the number of SNP markers needed to perform whole genome scans is divided by at least ten. Here, we propose a European effort gathering experts in genomics to take advantage of this extraordinary genetic model. Veterinary clinics from 12 European countries will collect DNA samples from large cohorts of dogs suffering from a range of thoroughly defined diseases of relevance to human health. Once these different cohorts will be built, DNA samples will be sent to a centralized, high-throughput SNP genotyping facility. The SNP genotypes will be stored in central database and made available to participating collaborating centres, who will analyze the data with the support of dedicated statistical genetics platforms. Following genome wide association and fine-mapping candidate genes will be followed up at the molecular level by expert animal and human genomics centers. This innovative approach using the dog model will ultimately provide insights into the pathogenesis of common human diseases – its primary goal. Fields of science natural sciencesbiological sciencesgeneticsDNAagricultural sciencesanimal and dairy sciencedomestic animalsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineneurologynatural sciencesbiological sciencesgeneticsgenomes Keywords Dog SNPs complex traits disease mapping genome wide association human disease Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.1.1-7 - Genome-wide association studies in mammalian non-rodent models for the identification of genes relevant to human health and disease Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITE DE LIEGE EU contribution € 1 270 598,00 Address Place du 20 aout 7 4000 Liege Belgium See on map Region Région wallonne Prov. Liège Arr. Liège Activity type Higher or Secondary Education Establishments Administrative Contact Marilou Ramos Pamplona (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (22) Sort alphabetically Sort by EU Contribution Expand all Collapse all NORGES VETERNINAERHOGSKOLE Participation ended Norway EU contribution No data Address Ullevaalsveien 72 0033 Oslo See on map Activity type Higher or Secondary Education Establishments Administrative Contact Knut Børve (Prof) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UPPSALA UNIVERSITET Sweden EU contribution € 1 170 000,00 Address Von kraemers alle 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Marianne Wigenius (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SVERIGES LANTBRUKSUNIVERSITET Sweden EU contribution € 719 000,00 Address Almas alle 8 750 07 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Ingrid Ragnarsdotter Jajke (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 751 200,00 Address Oxford road M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Liz Fay (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELSINGIN YLIOPISTO Finland EU contribution € 855 000,00 Address Yliopistonkatu 3 00014 Helsingin yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Katariina Vainio-Mattila (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KOBENHAVNS UNIVERSITET Denmark EU contribution € 689 400,00 Address Norregade 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Kristoffersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ANIMAL HEALTH TRUST United Kingdom EU contribution € 684 500,00 Address Lanwades park kentford CB8 7UU Suffolk See on map Activity type Research Organisations Administrative Contact Caroline Reynolds (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET Norway EU contribution € 518 000,00 Address Universitetstunet 3 1433 As See on map Region Norge Oslo og Viken Viken Activity type Higher or Secondary Education Establishments Administrative Contact Knut Børve (Prof) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT UTRECHT Netherlands EU contribution € 504 096,00 Address Heidelberglaan 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Marcel Jansen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET BERN Switzerland EU contribution € 359 400,00 Address Hochschulstrasse 6 3012 Bern See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne Activity type Higher or Secondary Education Establishments Administrative Contact Tosso Leeb (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 349 400,00 Address Trinity 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