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Unravelling the molecular basis of common complex human disorders using the dog as a model system

Objective

Despite major efforts, identifying susceptibility genes for common human diseases - cancer, cardiovascular, inflammatory and neurological disorders - is difficult due to the complexity of the underlying causes. The dog population is composed of ~ 400 purebred breeds; each one is a genetic isolate with unique characteristics resulting from persistent selection for desired attributes or from genetic drift / inbreeding. Dogs tend to suffer from the same range of diseases than human but the genetic complexity of these diseases within a breed is reduced as a consequence of the genetic drift and – due to long-range linkage disequilibrium – the number of SNP markers needed to perform whole genome scans is divided by at least ten. Here, we propose a European effort gathering experts in genomics to take advantage of this extraordinary genetic model. Veterinary clinics from 12 European countries will collect DNA samples from large cohorts of dogs suffering from a range of thoroughly defined diseases of relevance to human health. Once these different cohorts will be built, DNA samples will be sent to a centralized, high-throughput SNP genotyping facility. The SNP genotypes will be stored in central database and made available to participating collaborating centres, who will analyze the data with the support of dedicated statistical genetics platforms. Following genome wide association and fine-mapping candidate genes will be followed up at the molecular level by expert animal and human genomics centers. This innovative approach using the dog model will ultimately provide insights into the pathogenesis of common human diseases – its primary goal.

Field of science

  • /natural sciences/biological sciences/genetics and heredity
  • /agricultural sciences/animal and dairy science/pets
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITE DE LIEGE
Address
Place Du 20 Aout 7
4000 Liege
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 270 598
Administrative Contact
Marilou Ramos Pamplona (Dr.)

Participants (22)

NORGES VETERNINAERHOGSKOLE

Participation ended

Norway
Address
Ullevaalsveien 72
0033 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Knut Børve (Prof)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 1 170 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marianne Wigenius (Ms.)
SVERIGES LANTBRUKSUNIVERSITET
Sweden
EU contribution
€ 719 000
Address
Almas Alle 8
750 07 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingrid Ragnarsdotter Jajke (Ms.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 751 200
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 855 000
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katariina Vainio-Mattila (Ms.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 689 400
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
ANIMAL HEALTH TRUST
United Kingdom
EU contribution
€ 684 500
Address
Lanwades Park Kentford
CB8 7UU Suffolk
Activity type
Research Organisations
Administrative Contact
Caroline Reynolds (Dr.)
NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET
Norway
EU contribution
€ 518 000
Address
Universitetstunet 3
1433 As
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Knut Børve (Prof)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 504 096
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marcel Jansen (Mr.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 359 400
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tosso Leeb (Prof.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 349 400
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dawn Barker (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 422 400
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Florence Morineau (Ms.)
ANTAGENE
France
EU contribution
€ 330 000
Address
Allee Des Sequoias 2, Immeuble Le Meltem
69760 Limonest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guillaume Queney (Dr.)
ECOLE NATIONALE VETERINAIRE D'ALFORT
France
EU contribution
€ 230 000
Address
Avenue Du General De Gaulle 7
94704 Maisons-alfort
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bernard Gauthier (Mr.)
THE ROYAL VETERINARY COLLEGE
United Kingdom
EU contribution
€ 220 000
Address
Royal College Street
NW1 OTU London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Turhan Alasya (Mr.)
UNIVERSIDAD AUTONOMA DE BARCELONA
Spain
EU contribution
€ 150 000
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katja Shustakowitz (Ms.)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 150 000
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal Doolan (Mr.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 115 000
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colin Cooper (Mr.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 70 000
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Martha Sekey (Ms.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 75 000
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kartin Hartmann (Prof.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 93 000
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 2 272 000
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Elizabeth May (Ms.)