Unravelling the molecular basis of common complex human disorders using the dog as a model system

Project Information

LUPA

Grant agreement ID: 201370

Project closed

Start date 1 January 2008

End date 30 June 2012

Funded under

• Specific Programme "Cooperation": Health

Total cost € 15 677 376,24

EU contribution € 11 997 994,00

Coordinated by

UNIVERSITE DE LIEGE
Belgium

Objective

Despite major efforts, identifying susceptibility genes for common human diseases - cancer, cardiovascular, inflammatory and neurological disorders - is difficult due to the complexity of the underlying causes. The dog population is composed of ~ 400 purebred breeds; each one is a genetic isolate with unique characteristics resulting from persistent selection for desired attributes or from genetic drift / inbreeding. Dogs tend to suffer from the same range of diseases than human but the genetic complexity of these diseases within a breed is reduced as a consequence of the genetic drift and – due to long-range linkage disequilibrium – the number of SNP markers needed to perform whole genome scans is divided by at least ten. Here, we propose a European effort gathering experts in genomics to take advantage of this extraordinary genetic model. Veterinary clinics from 12 European countries will collect DNA samples from large cohorts of dogs suffering from a range of thoroughly defined diseases of relevance to human health. Once these different cohorts will be built, DNA samples will be sent to a centralized, high-throughput SNP genotyping facility. The SNP genotypes will be stored in central database and made available to participating collaborating centres, who will analyze the data with the support of dedicated statistical genetics platforms. Following genome wide association and fine-mapping candidate genes will be followed up at the molecular level by expert animal and human genomics centers. This innovative approach using the dog model will ultimately provide insights into the pathogenesis of common human diseases – its primary goal.

Fields of science

Not validated

• natural sciences › biological sciences › genetics › DNA
• agricultural sciences › animal and dairy science › domestic animals
• medical and health sciences › clinical medicine › oncology
• medical and health sciences › basic medicine › neurology
• natural sciences › biological sciences › genetics › genomes

Keywords

• Dog
• SNPs
• complex traits
• disease mapping
• genome wide association
• human disease

Programme(s)

• FP7-HEALTH - Specific Programme "Cooperation": Health

Topic(s)

• HEALTH-2007-2.1.1-7 - Genome-wide association studies in mammalian non-rodent models for the identification of genes relevant to human health and disease

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITE DE LIEGE

• EU contribution: € 1 270 598,00
• Address: PLACE DU 20 AOUT 7 ; 4000 Liege ; Belgium
• Region: Région wallonne › Prov. Liège › Arr. Liège
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Marilou Ramos Pamplona (Dr.)
• Total cost: No data

Participants (22)

NORGES VETERNINAERHOGSKOLE

Participation ended

Norway

• EU contribution: No data
• Address: Ullevaalsveien 72 ; 0033 OSLO
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Knut Børve (Prof)
• Total cost: No data

UPPSALA UNIVERSITET

Sweden

• EU contribution: € 1 170 000,00
• Address: VON KRAEMERS ALLE 4 ; 751 05 Uppsala
• Region: Östra Sverige › Östra Mellansverige › Uppsala län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Marianne Wigenius (Ms.)
• Total cost: No data

SVERIGES LANTBRUKSUNIVERSITET

Sweden

• EU contribution: € 719 000,00
• Address: ALMAS ALLE 8 ; 750 07 Uppsala
• Region: Östra Sverige › Östra Mellansverige › Uppsala län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ingrid Ragnarsdotter Jajke (Ms.)
• Total cost: No data

THE UNIVERSITY OF MANCHESTER

United Kingdom

• EU contribution: € 751 200,00
• Address: OXFORD ROAD ; M13 9PL Manchester
• Region: North West (England) › Greater Manchester › Manchester
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Liz Fay (Ms.)
• Total cost: No data

HELSINGIN YLIOPISTO

Finland

• EU contribution: € 855 000,00
• Address: FABIANINKATU 33 ; 00014 HELSINGIN YLIOPISTO
• Region: Manner-Suomi › Helsinki-Uusimaa › Helsinki-Uusimaa
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Katariina Vainio-Mattila (Ms.)
• Total cost: No data

KOBENHAVNS UNIVERSITET

Denmark

• EU contribution: € 689 400,00
• Address: NORREGADE 10 ; 1165 Kobenhavn
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ivan Kristoffersen (Mr.)
• Total cost: No data

ANIMAL HEALTH TRUST

United Kingdom

• EU contribution: € 684 500,00
• Address: LANWADES PARK KENTFORD ; CB8 7UU SUFFOLK
• Activity type: Research Organisations
• Administrative Contact: Caroline Reynolds (Dr.)
• Total cost: No data

NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET

Norway

• EU contribution: € 518 000,00
• Address: UNIVERSITETSTUNET 3 ; 1433 As
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Knut Børve (Prof)
• Total cost: No data

UNIVERSITEIT UTRECHT

Netherlands

• EU contribution: € 504 096,00
• Address: HEIDELBERGLAAN 8 ; 3584 CS Utrecht
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Marcel Jansen (Mr.)
• Total cost: No data

UNIVERSITAET BERN

Switzerland

• EU contribution: € 359 400,00
• Address: HOCHSCHULSTRASSE 6 ; 3012 Bern
• Region: Schweiz/Suisse/Svizzera › Espace Mittelland › Bern / Berne
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tosso Leeb (Prof.)
• Total cost: No data

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

• EU contribution: € 349 400,00
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Dawn Barker (Ms.)
• Total cost: No data

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

• EU contribution: € 422 400,00
• Address: RUE MICHEL ANGE 3 ; 75794 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Florence Morineau (Ms.)
• Total cost: No data

ANTAGENE

France

• EU contribution: € 330 000,00
• Address: ALLEE DES SEQUOIAS 2, IMMEUBLE LE MELTEM ; 69760 LIMONEST
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Guillaume Queney (Dr.)
• Total cost: No data

ECOLE NATIONALE VETERINAIRE D'ALFORT

France

• EU contribution: € 230 000,00
• Address: Avenue du General de Gaulle 7 ; 94704 MAISONS-ALFORT
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Bernard Gauthier (Mr.)
• Total cost: No data

THE ROYAL VETERINARY COLLEGE

United Kingdom

• EU contribution: € 220 000,00
• Address: ROYAL COLLEGE STREET ; NW1 OTU London
• Region: London › Outer London — West and North West › Barnet
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Turhan Alasya (Mr.)
• Total cost: No data

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

• EU contribution: € 150 000,00
• Address: EDIF A CAMPUS DE LA UAB BELLATERRA CERDANYOLA V ; 08193 Cerdanyola Del Valles
• Region: Este › Cataluña › Barcelona
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Katja Shustakowitz (Ms.)
• Total cost: No data

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

• EU contribution: € 150 000,00
• Address: BELFIELD ; 4 Dublin
• Region: Ireland › Eastern and Midland › Dublin
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Donal Doolan (Mr.)
• Total cost: No data

THE UNIVERSITY OF LIVERPOOL

United Kingdom

• EU contribution: € 115 000,00
• Address: BROWNLOW HILL 765 FOUNDATION BUILDING ; L69 7ZX Liverpool
• Region: North West (England) › Merseyside › Liverpool
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Colin Cooper (Mr.)
• Total cost: No data

University of Zurich

Switzerland

• EU contribution: € 70 000,00
• Address: RAMISTRASSE 71 ; 8006 ZURICH
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Martha Sekey (Ms.)
• Total cost: No data

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

• EU contribution: € 75 000,00
• Address: GESCHWISTER SCHOLL PLATZ 1 ; 80539 MUNCHEN
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Kartin Hartmann (Prof.)
• Total cost: No data

THE UNIVERSITY OF NOTTINGHAM

United Kingdom

• EU contribution: € 93 000,00
• Address: University Park ; NG7 2RD Nottingham
• Region: East Midlands (England) › Derbyshire and Nottinghamshire › Nottingham
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Paul Cartledge (Mr.)
• Total cost: No data

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 2 272 000,00
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Elizabeth May (Ms.)
• Total cost: No data