The lab-free CBRN detection device for the identification of biological pathogens on nucleic acid and immunological level as lab-on-a-chip system applying multisensor technologies

Objective

The goal of MultiSENSE is the development of a detection and identification system for biological pathogens, which shall include both the sample preparation stage, during which target molecules are extracted directly and in parallel the ensuing nucleic-acid-based and/or immunological detection and identification steps, in order to build an integrated “sample in, result out” system. Disruptive technologies (e.g. advanced sensor technologies like optoelectronic sensors or electrochemical sensors), lab-on-chip technology, and innovative instrumentation are key to reaching the presently unrealized goal of identifying pathogens in parallel on both the molecular biology level via PCR and the immunological route.
The chosen technologies offer several advantages: on the one hand, a small, portable, and easy-to-use device can be realized due to miniaturization; on the other, the so-called lab-on-chip technology enables operation outside of lab settings, meaning that the complete analysis including sample preparation, extraction of target molecules, etc. will be carried out in a small device the size of a microtiter plate with all necessary reagents on board. This includes dry reagent storage of lysis reagents, master mixes for the PCR, antibodies, and liquid storage of buffers. Furthermore, it will be imperative that an on-chip waste storage be included in order to eliminate contamination risk. The overall target is a “sample in, result out”-type handling procedure.
A reduction of processing times is a further advantage owed to miniaturization and the combination of all biological processes in a small disposable chip instead of different instruments. Finally, suitably equipped biological laboratories are no longer necessary to run PCR and immunological assays as portable systems may instead be used to analyze suspicious samples directly at the point of interest. Sensor technology will be another enabling technology we will apply.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• natural sciences biological sciences biochemistry biomolecules nucleic acids
• engineering and technology other engineering and technologies microtechnology lab on a chip
• engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
• natural sciences biological sciences molecular biology

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

• FP7-SECURITY - Specific Programme "Cooperation": Security

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

• SEC-2010.4.2-2 - Preparedness and Resilience to a CBRN crisis

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-SEC-2010-1
See other projects for this call

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CP - Collaborative project (generic)

Coordinator

Participants (8)