'Cell senescence in cancer and ageing', Cambridge, UK
Biological aging or senescence is the inherent process of accumulated changes to molecular and cellular structure. They disrupt an organism's biology with time, eventually resulting in deterioration and death. Senescence occurs both on the level of the whole organism as well as on the level of its individual cells.
Some research evidence now indicates that cell senescence is a potent tumour suppression mechanism through its ability to block proliferation of incipient cancer cells. However, senescence is not simply a passive proliferation arrest that impacts only the senescent cell itself. The latter influences its environment and neighbouring cells through an active secretory program. This secretory program appears to facilitate senescence as a tumor suppression process.
This conference will be a forum for researchers to discuss the mechanisms of senescence, the impact of senescence on cancer and ageing, and avenues to exploit senescence in cancer and disease therapies.For further information, please visit:
http://registration.hinxton.wellcome.ac.uk/display_info.asp?id=342