Exploiting the full potential of in-silico medicine research for personalised diagnostics and therapies in cloud-based environments Proposals are expected to develop and validate software tools and devices for diagnostic or treatment based on computational modelling and simulation applied in biology and physiology. The solutions should enable decision making in complex situations and contribute to a more precise and personalised management of diseases in order to reduce the burden of non-communicable diseases, such as cancer.Computer-based decision making can apply to the choice of drugs, devices or other biomedical products, procedures, interventions, in vitro and in vivo diagnostics methods and tools, or combined diagnostics and treatments. In order to ensure access to large multi-disciplinary high quality data sets and diminish the shortage of relevant data, the teams are expected to use shared infrastructures and e-infrastructures, building on existing capacity and expertise and linking where possible with the European initiatives that manage databases relevant for personal health, such as BBMRI, ELIXIR or EATRIS, as well as with Centres of Excellences for computing applications in the area of biomedicine and bio-molecular research[[https://ec.europa.eu/programmes/horizon2020/en/news/overview-eu-funded-centres-excellence-computing-applications]] as appropriate. They should demonstrate access to the sufficient and relevant clinical data needed for advanced validations. The work should build on – and contribute to reusable data and computer models. Teams are encouraged to use EOSC services as appropriate and possible.The Commission considers that proposals requesting a contribution from the EU of between EUR 10 and 15 million would allow this specific challenge to be addressed appropriately. Nonetheless, this does not preclude submission and selection of proposals requesting other amounts. The progress in computer modelling and simulation applied in disease management is a European strength and various Decision Support Systems have been developed for different medical disciplines.While the market is developing today, addressing the need of more precise and personalised diagnostics and treatments, the proposed software tools and platforms often need to further conquer visibility and trust from users and investors to get implemented in the routine clinical practice. The access of researchers to high quality big data and in particular to clinical multi-disciplinary data is crucial for validating the use of new tools and platforms in the right practice context.Through its new initiatives on digital health and care within the Digital Single Market policy[[See http://europa.eu/rapid/press-release_IP-17-1232_en.htm]], the European Commission aims at leveraging the potential of big data and high performance computing for the emergence of new personalised prevention and treatments for European citizens. The European Cloud Initiative will facilitate the access of researchers to the newest data managing technologies, High Performance Computing facilities to process data and to a European Open Science Cloud list of ICT services while ensuring the appropriate data safety and protection.Shared infrastructures, data and services in open cloud-based environments will stimulate the virtual complex experimentations in medicine and the link between researchers and healthcare practitioners, for their common benefit. The proposal should provide appropriate indicators to measure its progress and specific impact in the following areas: Better translation of big and multi-disciplinary data into predictors for medical outcome and personalised decision making; New digitised trusted diagnostic and treatment tools, and contributing to digitising clinical workflows; Improved disease management, demonstrated in the specific disease context; Links to other European research infrastructure projects and networks operating in related domains; Contribution to the emergence of a European Data Infrastructure for personalised medicine in the context of the DSM, notably by providing reusable data and computer models for personalised prevention and health treatments; Better data quality, interoperability and standards.