New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

Project description

Heart-to-heart evaluation could lead to tissue regeneration therapies

A heart attack, technically a myocardial infarction, is generally an ischaemic event in which vital oxygen and nutrients are denied to heart muscle (myocardium), because of either a vessel blockage or rupture. This typically results in tissue death and subsequent scarring, diminishing the heart's capacity to pump blood efficiently. Over time, this can potentially lead to heart failure. The human heart does not regenerate cells and tissue; likewise, introduction of stem cells has not been associated with regeneration. However, some fish and amphibian species can regenerate their hearts. The EU-funded REANIMA project is studying the presence and absence of such regeneration across diverse species, seeking pathways toward regeneration and mechanisms stimulating endogenous regeneration in humans. A well-established translational pipeline could bring discoveries to the clinic speedily.

Fields of science

• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drug

Programme(s)

• H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being
• H2020-EU.3.1.3. - Treating and managing disease

Topic(s)

• SC1-BHC-07-2019 - Regenerative medicine: from new insights to new applications

Call for proposal

H2020-SC1-2019-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)

Address

Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain

Activity type

Research Organisations

EU contribution

€ 1 380 000

Participants (11)

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Germany

EU contribution

€ 780 000

Address

Martinistrasse 52
20251 Hamburg

Activity type

Higher or Secondary Education Establishments

KING'S COLLEGE LONDON

United Kingdom

EU contribution

€ 780 000

Address

Strand
WC2R 2LS London

Activity type

Higher or Secondary Education Establishments

UNIVERSITAET BERN

Switzerland

EU contribution

€ 780 000

Address

Hochschulstrasse 6
3012 Bern

Activity type

Higher or Secondary Education Establishments

FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH

Austria

EU contribution

€ 780 000

Address

Campus-vienna-biocenter 1
1030 Wien

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

WEIZMANN INSTITUTE OF SCIENCE

Israel

EU contribution

€ 780 000

Address

Herzl Street 234
7610001 Rehovot

Activity type

Higher or Secondary Education Establishments

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Netherlands

EU contribution

€ 780 000

Address

Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam

Activity type

Other

ETHRIS GMBH

Germany

EU contribution

€ 450 000

Address

Semmelweisstr. 3
82152 Planegg

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

ZECLINICS SL

Spain

EU contribution

€ 250 000

Address

Ctra De Can Ruti, Cami De Les Escoles, S/n Laboratori P0-8, Edifici Igtp Muntanya
08916 Barcelona

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

DEUTSCHES PRIMATENZENTRUM GMBH

Germany

EU contribution

€ 710 000

Address

Kellnerweg 4
37077 Gottingen

Activity type

Research Organisations

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA

Italy

EU contribution

€ 400 000

Address

Piazza Martiri Della Liberta 33
56127 Pisa

Activity type

Higher or Secondary Education Establishments

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU contribution

€ 130 000

Address

Hansastrasse 27C
80686 Munchen

Activity type

Research Organisations