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New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

Project description

Heart-to-heart evaluation could lead to tissue regeneration therapies

A heart attack, technically a myocardial infarction, is generally an ischaemic event in which vital oxygen and nutrients are denied to heart muscle (myocardium), because of either a vessel blockage or rupture. This typically results in tissue death and subsequent scarring, diminishing the heart's capacity to pump blood efficiently. Over time, this can potentially lead to heart failure. The human heart does not regenerate cells and tissue; likewise, introduction of stem cells has not been associated with regeneration. However, some fish and amphibian species can regenerate their hearts. The EU-funded REANIMA project is studying the presence and absence of such regeneration across diverse species, seeking pathways toward regeneration and mechanisms stimulating endogenous regeneration in humans. A well-established translational pipeline could bring discoveries to the clinic speedily.

Call for proposal

H2020-SC1-2019-Single-Stage-RTD
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Coordinator

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 1 380 000

Participants (11)

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 780 000
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 780 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET BERN
Switzerland
EU contribution
€ 780 000
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria
EU contribution
€ 780 000
Address
Campus-vienna-biocenter 1
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 780 000
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
EU contribution
€ 780 000
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Activity type
Other
ETHRIS GMBH
Germany
EU contribution
€ 450 000
Address
Semmelweisstr. 3
82152 Planegg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ZECLINICS SL
Spain
EU contribution
€ 250 000
Address
Ctra De Can Ruti, Cami De Les Escoles, S/n Laboratori P0-8, Edifici Igtp Muntanya
08916 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DEUTSCHES PRIMATENZENTRUM GMBH
Germany
EU contribution
€ 710 000
Address
Kellnerweg 4
37077 Gottingen
Activity type
Research Organisations
SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Italy
EU contribution
€ 400 000
Address
Piazza Martiri Della Liberta 33
56127 Pisa
Activity type
Higher or Secondary Education Establishments
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 130 000
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations