Project description
Heart-to-heart evaluation could lead to tissue regeneration therapies
A heart attack, technically a myocardial infarction, is generally an ischaemic event in which vital oxygen and nutrients are denied to heart muscle (myocardium), because of either a vessel blockage or rupture. This typically results in tissue death and subsequent scarring, diminishing the heart's capacity to pump blood efficiently. Over time, this can potentially lead to heart failure. The human heart does not regenerate cells and tissue; likewise, introduction of stem cells has not been associated with regeneration. However, some fish and amphibian species can regenerate their hearts. The EU-funded REANIMA project is studying the presence and absence of such regeneration across diverse species, seeking pathways toward regeneration and mechanisms stimulating endogenous regeneration in humans. A well-established translational pipeline could bring discoveries to the clinic speedily.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- natural sciencesbiological scienceszoologymammalogy
- medical and health sciencesclinical medicinecardiology
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
28029 Madrid
Spain
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Participants (11)
20251 Hamburg
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WC2R 2LS London
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3012 Bern
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1030 Wien
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7610001 Rehovot
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1011 JV Amsterdam
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82152 Planegg
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
08916 Barcelona
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
37077 Gottingen
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56127 Pisa
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80686 Munchen
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