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New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms

Project description

Heart-to-heart evaluation could lead to tissue regeneration therapies

A heart attack, technically a myocardial infarction, is generally an ischaemic event in which vital oxygen and nutrients are denied to heart muscle (myocardium), because of either a vessel blockage or rupture. This typically results in tissue death and subsequent scarring, diminishing the heart's capacity to pump blood efficiently. Over time, this can potentially lead to heart failure. The human heart does not regenerate cells and tissue; likewise, introduction of stem cells has not been associated with regeneration. However, some fish and amphibian species can regenerate their hearts. The EU-funded REANIMA project is studying the presence and absence of such regeneration across diverse species, seeking pathways toward regeneration and mechanisms stimulating endogenous regeneration in humans. A well-established translational pipeline could bring discoveries to the clinic speedily.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2019-Single-Stage-RTD

Coordinator

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Net EU contribution
€ 1 380 000,00
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (11)

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
Net EU contribution
€ 780 000,00
Address
Martinistrasse 52
20251 Hamburg

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 780 000,00
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET BERN
Switzerland
Net EU contribution
€ 780 000,00
Address
Hochschulstrasse 6
3012 Bern

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH
Austria
Net EU contribution
€ 780 000,00
Address
Campus-vienna-biocenter 1
1030 Wien

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Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 780 000,00
Address
Herzl Street 234
7610001 Rehovot

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands
Net EU contribution
€ 780 000,00
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Non-EU contribution
€ 0,00
ETHRIS GMBH
Germany
Net EU contribution
€ 450 000,00
Address
Semmelweisstr. 3
82152 Planegg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Landkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ZECLINICS SL
Spain
Net EU contribution
€ 250 000,00
Address
Ctra De Can Ruti, Cami De Les Escoles, S/n Laboratori P0-8, Edifici Igtp Muntanya
08916 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
DEUTSCHES PRIMATENZENTRUM GMBH
Germany
Net EU contribution
€ 710 000,00
Address
Kellnerweg 4
37077 Gottingen

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Region
Niedersachsen Braunschweig Göttingen
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Italy
Net EU contribution
€ 400 000,00
Address
Piazza Martiri Della Liberta 33
56127 Pisa

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Region
Centro (IT) Toscana Pisa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 130 000,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00