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Analysing combination effects of mixtures of estrogenic chemicals in marine and freshwater organisms

Objective

There is growing concern among European Union citizens about chemicals that are suspected of disrupting reproduction in aquatic organisms. Natural estrogens and synthetic chemicals with estrogenic activity have adversely affected a variety of fish. A crucial aspect of identifying the causes of endocrine disruption in aquatic systems is to analyse how chemicals implicated as causative agents might act when present as mixtures. This project aims at improving our understanding of the effects of combinations of multiple estrogenic chemicals and other toxicants on aquatic organisms. It brings together expertise from fish biology, endocrinology, biometry, statistics and analytical chemistry. Mixture effects of combinations of multiple estrogenic chemicals will be assessed and predicted at the sub cellular, cellular, and physiological and organism levels by using a variety of estrogenicity assays.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

BRUNEL UNIVERSITY
Address
Kingston Lane
Uxbridge
United Kingdom

Participants (6)

CENTER FOR MARINE AND ENVIRONMENTAL RESEARCH (CIIMAR)
Portugal
Address
Rua Do Campo Alegre 823
4150-180 Porto
THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON
United Kingdom
Address
Brunswick Square 29-39
WC1N 1AX London
UNIVERSITA CA' FOSCARI DI VENEZIA
Italy
Address
Calle Larga Santa Marta 2137
30123 Venezia
UNIVERSITAET BREMEN
Germany
Address
2,Loebener Strasse 2
28344 Bremen
VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS
Netherlands
Address
De Boelelaan 1115
1081 HV Amsterdam
VRIJE UNIVERSITEIT AMSTERDAM - VERENIGING VOOR CHRISTELIJK WETENSCHAPPELIJK ONDERWIJS
Netherlands
Address
1083,De Boelelaan 1083
1081 HV Amsterdam