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Calcium, the backbone of fish culture: Importance in skeletal formation, reproduction and normal physiology

Objective

The first objective is to identify the relative importance of the different sources of calcium during critical phases of development, growth and reproduction during a normal production cycle on a fish farm. The second objective is to determine experimentally whole animal calcium homeostasis during larval development, vitellogenesis and normal growth and the role of PTHrP in maintaining homeostasis. These will be related to observations of calcium requirements and balance made on the fish farm. The third objective will be to determine the molecular mechanisms, which underpin bone formation in fish and the way in which PTHrP regulates this process.

The PTHrP gene promoter(s) will be identified and used to characterise factors, which may influence its expression in vivo. Genes differentially expressed during endochondral bone formation, and thus strong candidate genes for this process will be isolated and their regulation by PTHrP determined.

Coordinator

UNIVERSIDADE DO ALGARVE
Address
Campus De Gambelas
Faro
Portugal

Participants (7)

DOUBLE DELTA KERESKEDELMI TERMELO ES KUTATASFEJLESZTESI BETETI TARSASAG
Hungary
Address
Hullam 12
Berettyoujfalu
KATHOLIEKE UNIVERSITEIT NIJMEGEN
Netherlands
Address
Toernooiveld 1
Nijmegen
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Wellcome Genome Campus Hinxton
Cambridge
NATURAL ENVIRONMENT RESEARCH COUNCIL
United Kingdom
Address
High Cross Madingley Road
Cambridge
POLISH ACADEMY OF SCIENCES INSTITUTE OF OCEANOLOGY
Poland
Address
Powstancow Warszawy, 55
Sopot
UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
VIVEIRO VILANOVA S.A.
Portugal
Address
Foros Do Galeado
Vila Nova De Milfontes