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Development of a pathogen epitope prediction program, and evaluation of its usefulness in designing fish vaccines

Objective

Representing a principal novel approach, peptide vaccines have been successfully developed in higher vertebrates. Here, exact knowledge on which part(s) of the virus can bind and stimulate the immune system is established and exploited in vaccine production. There is now sufficient immunological information to develop this technology in fish. This, our main objective, will be achieved by identifying and exploiting the functional restrictions of a host immune molecules, the major histocompatibility complex (MHC) class I molecule. The project will generate much needed reagents for a multitude of functional studies in fish, increase the general knowledge on fish immunology and bring Europe to the frontier of aquacultural research. It will also enable design of antigenic peptide vaccines matching the immune-specific constitution of the production population.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF OSLO
Address
Sem Seelands Vei 2
0316 Oslo
Norway

Participants (3)

Institute for Animal Health
United Kingdom
Address
Compton Laboratory Compton
RG16 0NN Newbury
NATIONAL UNIVERSITY OF IRELAND, GALWAY
Ireland
Address

90 Galway
UNIVERSITY OF SOUTHERN DENMARK - UNIVERSITY OF ODENSE
Denmark
Address
Winsloeevparken 21
5000 Odense