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Genetic mechanisms involving ultraviolet light in the development of cutaneous malignant melanoma

Objective

Cutaneous malignant melanoma (CMM) is one of the most feared of all cancers because of the high degree of malignancy it displays at a very early stage. CMM has been increasing in incidence faster than any other cancer, possibly because of increasing recreational exposure to sunlight. However, proof of a firm mechanistic link to specific types of sunlight-induced DNA damage is needed before preventative advice can be given to the public with confidence. In this project, we will identify and isolate genes damaged in the various stages of melanoma genesis and use these, together with know cancer-related genes, as molecular reporters to establish the precise roles of various spectral components of UV in CMM development. This work will be complemented by directly demonstrating induction of CMM events by UV and heat (sunburn) in rodent (in vivo) and human cell culture (in vitro) model systems.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

BRUNEL UNIVERSITY
Address
Kingston Lane
Uxbridge
United Kingdom

Participants (7)

GERMAN CANCER RESEARCH CENTER
Germany
Address
Im Neuenheimer Feld 280
69120 Heidelberg
ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI
Italy
Address
Via Venezian 1
20133 Milano
LEIDEN UNIVERSITY
Netherlands
Address
Wassenaarseweg 72
2300 RA Leiden
ROSTOCK UNIVERSITY
Germany
Address
Universitaetsplatz 1
18055 Rostock
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
Address
Cranmer Terrace
London
UNIVERSITAET KOELN
Germany
Address
Joseph-stelzmann-srasse 52
50931 Koeln
WISE & MUNRO LEARNING RESEARCH
Netherlands
Address
8,Azaleastraat 85
2565 CD Den Haag