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Increasing incidence of human male reproductive health disorders in relation to environmental effects on growth- and sex steroid-induced alterations in programmed development.

Objective

Using standardised methods, we will established incidence rates for urogenital malformations in male infants in EU countries, and differences in sperm counts among countries and age cohorts. We will search for causes of reproductive disorders, with emphasis on environmental exposures of mothers. To underpin these clinical studies, experiments in rats will establish how alterations to the sex steroid environment of the fetus/neonate affect expression of programming genes involved in reproductive tract and digit development. Studies will also establish whether these parameters and sex steroid levels are affect by exposure to putative endocrine disruptors (emphasis on meat hormones, e.g. zearalanol ) , or by intrauterine growth retadation (risk factor for male reproductive abnormalities) . A database will be created for future monitoring purposes. The project will evaluate tests to enable detection of altered fetal sex steroid exposure.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

COPENHAGEN UNIVERSITY HOSPITAL
Address
Blegdamsvej 9
2100 Koepenhagen
Denmark

Participants (11)

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
France
Address
Avenue Victoria 3
75004 Paris
FAMILY AND SEXUAL HEALTH PROBLEMS CENTER
Latvia
Address
Rupniecibas, 19 B
1010 Riga
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
KAUNAS MEDICAL UNIVERSITY HOSPITAL
Lithuania
Address
Eiveniu 2
3007 Kaunas
Medical Research Council (MRC)
United Kingdom
Address
20 Park Crescent
W1N 4AL London
ST MARIANNA UNIVERSITY SCHOOL OF MEDECINE
Japan
Address
Sugao 2-16-1, Miyamae
210 85 Kawasaki
TARTU UNIVERSITY CLINICS
Estonia
Address
L. Puusepa 1A
50406 Tartu
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
Trinity Lane, The Old Schools,
CB2 1TN Cambridge
UNIVERSIDAD DE GRANADA
Spain
Address
Calle Cuesta Del Hospicio S/n, Hospital Real
18071 Granada
UNIVERSITY OF MISSOURI - COLUMBIA
United States
Address

65212 Columbia
UNIVERSITY OF TURKU
Finland
Address
Kiinamyllynkatu 13
20014 Turku