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Investigations on mechanisms for maintenance and regeneration in the ageing muscle : development of guidelines , diagnostic tools and a view to therapies

Objective

Diminution in muscular performance is a major cause of disablement in old age. This loss appears to be a multi component phenomenon. We will investigate whether and which factors within the muscle itself are responsible for this decline. A major goal of our network is to determine changes in the behaviour of the satellite cells during ageing (i.e. numbers, proliferate capacity in vitro and in vivo, gynogenic program, calcium homeostasis). Satellite cells are the only source for maintenance, growth and regeneration of muscle tissue. Important aspects of the contractile apparatus and capillarization will be investigated as well. Most work will be performed on human tissue in a cooperation of outstanding basic scientists and clinical partners. A diagnostic tool to predict trainability of muscle in the aged will be elaborated.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
Address
Nussallee 12
Bonn
Germany

Participants (6)

Medical Research Council (MRC)
United Kingdom
Address
20 Park Crescent
W1N 4AL London
UNIVERSITA DEGLI STUDI DI TRIESTE
Italy
Address
Piazzale Europa 1
34127 Trieste
UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI
France
Address
Place Jussieu 4
75252 Paris
UNIVERSITY OF LJUBLJANA
Slovenia
Address
Kongresni Trg 12
1000 Ljubljana
UNIVERSITY OF UMEAA
Sweden
Address
Universitetsomraadet
901 87 Umeaa
WARSAW AGRICULTURAL UNIVERSITY
Poland
Address
Ul. Rakowiecka, 26/30
02 528 Warszawa