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Global dynamics of topoisomerase-induced DNA breaks

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Publications

A Genetic Map of the Response to DNA Damage in Human Cells

Author(s): Michele Olivieri; Michele Olivieri; Tiffany Cho; Tiffany Cho; Alejandro Álvarez-Quilón; Kejiao Li; Matthew J. Schellenberg; Michal Zimmermann; Nicole Hustedt; Silvia Emma Rossi; Salomé Adam; Henrique Melo; Anne Margriet Heijink; Guillermo Sastre-Moreno; Nathalie Moatti; Rachel K. Szilard; Andrea McEwan; Alexanda K. Ling; Almudena Serrano-Benitez; Tajinder Ubhi; Sumin Feng; Judy Pawling; Irene D
Published in: Cell, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.05.040

ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links

Author(s): Matthew J. Schellenberg, Jenna Ariel Lieberman, Andrés Herrero-Ruiz, Logan R. Butler, Jason G. Williams, Ana M. Muñoz-Cabello, Geoffrey A. Mueller, Robert E. London, Felipe Cortés-Ledesma, R. Scott Williams
Published in: Science, 357/6358, 2017, Page(s) 1412-1416, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aam6468

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

Author(s): Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Ariel Lieberman, Silvia Jimeno-González, Sander Lambo, Bola S. Hanna, Yassin Harim, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanad Rajendran, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Peter Lichter, Felipe Cortés-Ledes
Published in: Nature Communications, 8, 2017, Page(s) 14758, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/ncomms14758

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

Author(s): Alejandro Álvarez-Quilón; José Terrón-Bautista; Irene Delgado-Sainz; Almudena Serrano-Benitez; Rocío Romero-Granados; Pedro Manuel Martínez-García; Silvia Jimeno-González; Cristina Bernal-Lozano; Cristina Quintero; Lourdes García-Quintanilla; Felipe Cortés-Ledesma
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-14638-w

Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.

Author(s): Matthew J. Schellenberg; C. Denise Appel; A.A. Riccio; Logan R. Butler; Juno M. Krahn; Jenna A Liebermann; Felipe Cortés-Ledesma; R. Scott Williams
Published in: Nucleic Acids Research, 2020, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa318

Genome-wide prediction of topoisomerase IIβ binding by architectural factors and chromatin accessibility

Author(s): Pedro Manuel Martínez-García; Miguel García-Torres; Federico Divina; José Terrón-Bautista; Irene Delgado-Sainz; Francisco Gómez-Vela; Felipe Cortés-Ledesma
Published in: PLoS Computational Biology, 2021, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1101/2020.03.23.003277

Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing.

Author(s): Andrés Herrero-Ruiz; Pedro Manuel Martínez-García; José Terrón-Bautista; Gonzalo Millán-Zambrano; Jenna Ariel Lieberman; Silvia Jimeno-González; Silvia Jimeno-González; Felipe Cortés-Ledesma
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108977

"""An End to a Means"": How DNA-End Structure Shapes the Double-Strand Break Repair Process."

Author(s): Almudena Serrano-Benítez; Felipe Cortés-Ledesma; Felipe Cortés-Ledesma; Jose F. Ruiz; Jose F. Ruiz
Published in: Frontiers in Molecular Biosciences, 2020, ISSN 2296-889X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fmolb.2019.00153