Objective
The domestication of plants and animals is increasingly being seen as a distinct evolutionary process. In cases such as that of the domestic dog, this process is shaped by practical requirements often intertwined with environmental stress. However, a convincing reconciliation of the rapid phenotypic alteration observed in early canine domesticates and the associated molecular evolution rates is yet to be modelled. The hypothesis of this project is that epigenetic activity, being increasingly seen as an evolutionary driver and known to be affected by environmental stress, is a central process to the evolution / domestication paradigm.
Archaeological samples of wolves and contemporary early dog domesticates provide an ideal dataset with which to explore this hypothesis. A large collection of such remains from different environs (Siberia, Greenland and Denmark), spanning a large time-scale from the Upper Paleolithic around 30,000 years before present, to the second millennium CE, present the opportunity to explore this hypothesis and identify molecular variation where domestication has taken different regional tracts. A combination of ancient DNA, ancient RNA, and advanced bioinformatic approaches will allow us to see not only the paleogenomic state, but how it fluctuates and evolves according to its environment.
Paleogenomic approaches to epigenetics are at the forefront of evolutionary biology and allow real-time snapshots of such evolutionary process to be observed. The combined expertise of the applicant and host institution in paleogenomic research, the state-of-the-art methodology proposed, and the global importance of dogs to humans will result in significant and high-impact output, beneficial to all concerned.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- agricultural sciences animal and dairy science domestic animals
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 Kobenhavn
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.