Developing multi-modality nanomedicines for targeted annotation of oncogenic signaling pathways

Project Information

NanoSCAN

Grant agreement ID: 676904

DOI 10.3030/676904

Project closed

EC signature date 25 May 2016

Start date 1 September 2016

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 700 000,00

EU contribution € 1 700 000,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (36)

Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging.

Author(s): Rachael Fay; Jason P. Holland
Published in: Chemistry A European Journal, Issue 12, 2021, Page(s) 4893-4897, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.202100061

The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody.

Author(s): Amaury Guillou; Daniel F. Earley; Simon Klingler; Eda Nisli; Laura J. Nüesch; Rachael Fay; Jason P. Holland
Published in: Bioconjugate Chemistry, Issue 12, 2021, Page(s) 1263–1275, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00172

Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles.

Author(s): Lamb, Jennifer; Fischer, Eliane; Rosillo-Lopez, Martin; Salzmann, Christoph G.; Holland, Jason P.
Published in: Chemical Science, Issue 13, 2019, Page(s) 8880-8888, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc03736e

Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's Disease.

Author(s): Cassis Varlow; Emily Murrell; Jason P. Holland; Alina Kassenbrock; Whitney Shannon; Whitney Shannon; Steven H. Liang; Neil Vasdev; Neil Vasdev; Neil Vasdev; Nickeisha A. Stephenson; Nickeisha A. Stephenson; Nickeisha A. Stephenson
Published in: Molecules, Issue 12, 2020, Page(s) 982, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25040982

Microfluidic Preparation of 89 Zr-Radiolabelled Proteins by Flow Photochemistry.

Author(s): Daniel F. Earley; Amaury Guillou; Dion van der Born; Alex J. Poot; Jason P. Holland
Published in: https://www.preprints.org/manuscript/202101.0379/v1, Issue 12, 2021, Page(s) 764, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26030764

Predicting the thermodynamic stability of zirconium radiotracers

Author(s): Holland, Jason P.
Published in: Inorganic Chemistry, Issue 12, 2020, Page(s) 2070-2082, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b03515

Charting the chemical and mechanistic scope of light-triggered protein ligation

Author(s): Earley, Daniel F.; Guillou, Amaury; Klingler, Simon; Fay, Rachael; Gut, Melanie; d’Orchymont, Faustine; Behmaneshfar, Shamisa; Reichert, Linus; Holland, Jason P.
Published in: JACS Au, Issue 12, 2022, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.1c00530

Computational studies on the Carboni-Lindsey reaction

Author(s): Klingler, Simon; Holland, Jason P.
Published in: Computational and Theoretical Chemistry, Issue 12, 2021, Page(s) 113161, ISSN 2210-271X
Publisher: Elsevier BV
DOI: 10.1016/j.comptc.2021.113161

Light-Activated Protein Conjugation and 89 Zr-Radiolabelling with Water-Soluble Desferrioxamine Derivatives.

Author(s): Amaury Guillou; Daniel F. Earley; Jason P. Holland
Published in: Chemistry A European Journal, Issue 12, 2020, Page(s) 7185-7189, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.202001755

Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold.

Author(s): Frei, Angelo; Fischer, Eliane; Childs, Bradley Covington; Holland, Jason P.; Alberto, Roger
Published in: Dalton Transactions, Issue 12, 2019, Page(s) 14600-14605, ISSN 1477-9234
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9dt02506e

Synthesis and Photochemical Studies on Gallium and Indium Complexes of DTPA-PEG3-ArN3 for Radiolabeling Antibodies.

Author(s): Gut, Melanie; Holland, Jason P.
Published in: Inorganic Chemistry, Issue 12, 2019, Page(s) 12302-12310., ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b01802

Photochemical Reactions in the Synthesis of Protein–Drug Conjugates

Author(s): Holland, Jason P; Gut, Melanie; Klingler, Simon; Fay, Rachael; Guillou, Amaury
Published in: Chemistry A European Journal, Issue 12, 2020, Page(s) 33-48, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.201904059

Graphene Nanoflake Antibody Conjugates for Multi-Modal Imaging of Tumors

Author(s): Jennifer Lamb; Joris Šimaitis; Siriney O. Halukeerthi; Christoph G. Salzmann; Jason P. Holland
Published in: Advanced Nanobiomed Research, Issue 12, 2021, Page(s) 2100009, ISSN 2699-9307
Publisher: Wiley
DOI: 10.1002/anbr.202100009

Light-induced radiosynthesis of 89ZrDFO-azepin-onartuzumab for imaging the hepatocyte growth factor receptor

Author(s): Klingler, Simon; Fay, Rachael; Holland, Jason P.
Published in: Journal of Nuclear Medicine, Issue 12, 2020, Page(s) 1072-1078, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.237180

Light-induced synthesis of protein conjugates and its application in photoradiosynthesis of 89Zr-radiolabeled monoclonal antibodies.

Author(s): Amaury Guillou; Daniel F. Earley; Malay Patra; Malay Patra; Jason P. Holland
Published in: Nature Protocols, Issue 12, 2020, Page(s) 3579–3594, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-0386-5

Automated light-induced synthesis of 89Zr-radiolabeled antibodies for immuno-positron emission tomography

Author(s): Klingler, Simon; Holland, Jason P.
Published in: Scientific Reports, Issue 12, 2022, Page(s) 668, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-04626-5

Radiochemistry and Preclinical PET Imaging of 68 Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen

Author(s): Eleni Gourni, Luigi Del Pozzo, Mark Bartholomä, Yvonne Kiefer, Philipp T. Meyer, Helmut R. Maecke, Jason P. Holland
Published in: Molecular Imaging, Issue 16, 2017, Page(s) 153601211773701, ISSN 1536-0121
Publisher: Sage Publications Inc.
DOI: 10.1177/1536012117737010

Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers

Author(s): Eszter Boros, Jason P. Holland
Published in: Journal of Labelled Compounds and Radiopharmaceuticals, 2018, ISSN 0362-4803
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3590

Advanced Methods for Radiolabeling Multimodality Nanomedicines for SPECT/MRI and PET/MRI

Author(s): Jennifer Lamb, Jason P. Holland
Published in: Journal of Nuclear Medicine, Issue 59/3, 2018, Page(s) 382-389, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.116.187419

Gallium Complexation, Stability, and Bioconjugation of 1,4,7-Triazacyclononane Derived Chelators with Azaheterocyclic Arms

Author(s): Alexander Schmidtke, Tilman Läppchen, Christian Weinmann, Lorenz Bier-Schorr, Manfred Keller, Yvonne Kiefer, Jason P. Holland, Mark D. Bartholomä
Published in: Inorganic Chemistry, Issue 56/15, 2017, Page(s) 9097-9110, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.7b01129

Recent applications of a single quadrupole mass spectrometer in 11 C, 18 F and radiometal chemistry

Author(s): Thomas L. Collier, Kenneth Dahl, Nickeisha A. Stephenson, Jason P. Holland, Adam Riley, Steven H. Liang, Neil Vasdev
Published in: Journal of Fluorine Chemistry, Issue 210, 2018, Page(s) 46-55, ISSN 0022-1139
Publisher: Elsevier BV
DOI: 10.1016/j.jfluchem.2018.02.009

In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate-specific membrane antigen targeting vector

Author(s): Tilman Läppchen, Yvonne Kiefer, Jason P. Holland, Mark D. Bartholomä
Published in: Nuclear Medicine and Biology, Issue 60, 2018, Page(s) 45-54, ISSN 0969-8051
Publisher: Elsevier BV
DOI: 10.1016/j.nucmedbio.2018.03.002

Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me

Author(s): Tilman Läppchen, Jason P. Holland, Yvonne Kiefer, Mark D. Bartholomä
Published in: EJNMMI Radiopharmacy and Chemistry, Issue 3/1, 2018, ISSN 2365-421X
Publisher: Springer
DOI: 10.1186/s41181-018-0043-2

Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me

Author(s): Christian Weinmann, Jason P. Holland, Tilman Läppchen, Harald Scherer, Stephan Maus, Tobias Stemler, Hendrik Bohnenberger, Samer Ezziddin, Philipp Kurz, Mark D. Bartholomä
Published in: Organic & Biomolecular Chemistry, Issue 16/40, 2018, Page(s) 7503-7512, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ob01981a

Photochemische Konjugation und Eintopfradiomarkierung von Antikörpern für Immun-PET

Author(s): Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland
Published in: Angewandte Chemie, Issue 131/7, 2019, Page(s) 1946-1951, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201813287

Frontispiece: Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET

Author(s): Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland
Published in: Angewandte Chemie International Edition, Issue 58/7, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201980761

Antibody-based radiopharmaceuticals for imaging and therapy

Author(s): Jason P. Holland
Published in: Journal of Labelled Compounds and Radiopharmaceuticals, Issue 61/9, 2018, Page(s) 610-610, ISSN 0362-4803
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3636

Chemical Kinetics of Radiolabelling Reactions

Author(s): Jason P. Holland
Published in: Chemistry - A European Journal, Issue 24/62, 2018, Page(s) 16472-16483, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201803261

Photoactive chelates for radiolabelling proteins

Author(s): Larissa S. Eichenberger, Malay Patra, Jason P. Holland
Published in: Chemical Communications, Issue 55/16, 2019, Page(s) 2257-2260, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc09660k

Simultaneous Photoradiochemical Labeling of Antibodies for Immuno-Positron Emission Tomography

Author(s): Malay Patra, Simon Klingler, Larissa S. Eichenberger, Jason P. Holland
Published in: iScience, Issue 13, 2019, Page(s) 416-431, ISSN 2589-0042
Publisher: Elsevier Inc.
DOI: 10.1016/j.isci.2019.03.004

The impact of emerging bioconjugation chemistries on radiopharmaceuticals

Author(s): Rachael Fay, Jason P. Holland
Published in: Journal of Nuclear Medicine, Issue 12, 2019, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.220806

Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET

Author(s): Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland
Published in: Angewandte Chemie International Edition, Issue 58/7, 2019, Page(s) 1928-1933, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201813287

Photoradiosynthesis of 68 Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors

Author(s): Rachael Fay, Melanie Gut, Jason P. Holland
Published in: Bioconjugate Chemistry, Issue 30/6, 2019, Page(s) 1814-1820, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00342

The Role of Molecular Imaging in Personalised Healthcare

Author(s): JasonP. Holland
Published in: CHIMIA International Journal for Chemistry, Issue 70/11, 2016, Page(s) 787-795, ISSN 0009-4293
Publisher: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2016.787

Expanding the chemistry palette for radiotracer synthesis

Author(s): Lamb, Jennifer; d’Orchymont, Faustine; Fay, Rachael; Gribi, Florian; Esteban Flores, Jose; Gut, Melanie; Klingler, Simon; Pires, Patricia; Bühler, Jan; Behmaneshfar, Shamisa; Guillou, Amaury; Earley, Daniel F.; Holland, Jason P.
Published in: Chimia, Issue 12, 2020, Page(s) 946-952, ISSN 2673-2424
Publisher: Chimia
DOI: 10.2533/chimia.2020.946

PhotoTag: Photoactivatable Fluorophores for Protein Labeling

Author(s): Fay, Rachael; Linden, Anthony; Holland, Jason P
Published in: Organic Letters, Issue 12, 2020, Page(s) 3499-3503, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.5167/uzh-187052