Developing multi-modality nanomedicines for targeted annotation of oncogenic signaling pathways

Project Information

NanoSCAN

Grant agreement ID: 676904

DOI 10.3030/676904

Project closed

EC signature date 25 May 2016

Start date 1 September 2016

End date 31 January 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 700 000,00

EU contribution € 1 700 000,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

Publications

Peer reviewed articles (36)

Tuning Tetrazole Photochemistry for Protein Ligation and Molecular Imaging.

Author(s): Rachael Fay; Jason P. Holland
Published in: Chemistry A European Journal, Issue 12, 2021, Page(s) 4893-4897, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.202100061

The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody.

Author(s): Amaury Guillou; Daniel F. Earley; Simon Klingler; Eda Nisli; Laura J. Nüesch; Rachael Fay; Jason P. Holland
Published in: Bioconjugate Chemistry, Issue 12, 2021, Page(s) 1263–1275, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.1c00172

Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles.

Author(s): Lamb, Jennifer; Fischer, Eliane; Rosillo-Lopez, Martin; Salzmann, Christoph G.; Holland, Jason P.
Published in: Chemical Science, Issue 13, 2019, Page(s) 8880-8888, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc03736e

Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's Disease.

Author(s): Cassis Varlow; Emily Murrell; Jason P. Holland; Alina Kassenbrock; Whitney Shannon; Whitney Shannon; Steven H. Liang; Neil Vasdev; Neil Vasdev; Neil Vasdev; Nickeisha A. Stephenson; Nickeisha A. Stephenson; Nickeisha A. Stephenson
Published in: Molecules, Issue 12, 2020, Page(s) 982, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25040982

Microfluidic Preparation of 89 Zr-Radiolabelled Proteins by Flow Photochemistry.

Author(s): Daniel F. Earley; Amaury Guillou; Dion van der Born; Alex J. Poot; Jason P. Holland
Published in: https://www.preprints.org/manuscript/202101.0379/v1, Issue 12, 2021, Page(s) 764, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26030764

Predicting the thermodynamic stability of zirconium radiotracers

Author(s): Holland, Jason P.
Published in: Inorganic Chemistry, Issue 12, 2020, Page(s) 2070-2082, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b03515

Charting the chemical and mechanistic scope of light-triggered protein ligation

Author(s): Earley, Daniel F.; Guillou, Amaury; Klingler, Simon; Fay, Rachael; Gut, Melanie; d’Orchymont, Faustine; Behmaneshfar, Shamisa; Reichert, Linus; Holland, Jason P.
Published in: JACS Au, Issue 12, 2022, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.1c00530

Computational studies on the Carboni-Lindsey reaction

Author(s): Klingler, Simon; Holland, Jason P.
Published in: Computational and Theoretical Chemistry, Issue 12, 2021, Page(s) 113161, ISSN 2210-271X
Publisher: Elsevier BV
DOI: 10.1016/j.comptc.2021.113161

Light-Activated Protein Conjugation and 89 Zr-Radiolabelling with Water-Soluble Desferrioxamine Derivatives.

Author(s): Amaury Guillou; Daniel F. Earley; Jason P. Holland
Published in: Chemistry A European Journal, Issue 12, 2020, Page(s) 7185-7189, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.202001755

Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold.

Author(s): Frei, Angelo; Fischer, Eliane; Childs, Bradley Covington; Holland, Jason P.; Alberto, Roger
Published in: Dalton Transactions, Issue 12, 2019, Page(s) 14600-14605, ISSN 1477-9234
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9dt02506e

Synthesis and Photochemical Studies on Gallium and Indium Complexes of DTPA-PEG3-ArN3 for Radiolabeling Antibodies.

Author(s): Gut, Melanie; Holland, Jason P.
Published in: Inorganic Chemistry, Issue 12, 2019, Page(s) 12302-12310., ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.9b01802

Photochemical Reactions in the Synthesis of Protein–Drug Conjugates

Author(s): Holland, Jason P; Gut, Melanie; Klingler, Simon; Fay, Rachael; Guillou, Amaury
Published in: Chemistry A European Journal, Issue 12, 2020, Page(s) 33-48, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.201904059

Graphene Nanoflake Antibody Conjugates for Multi-Modal Imaging of Tumors

Author(s): Jennifer Lamb; Joris Šimaitis; Siriney O. Halukeerthi; Christoph G. Salzmann; Jason P. Holland
Published in: Advanced Nanobiomed Research, Issue 12, 2021, Page(s) 2100009, ISSN 2699-9307
Publisher: Wiley
DOI: 10.1002/anbr.202100009

Light-induced radiosynthesis of 89ZrDFO-azepin-onartuzumab for imaging the hepatocyte growth factor receptor

Author(s): Klingler, Simon; Fay, Rachael; Holland, Jason P.
Published in: Journal of Nuclear Medicine, Issue 12, 2020, Page(s) 1072-1078, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.237180

Light-induced synthesis of protein conjugates and its application in photoradiosynthesis of 89Zr-radiolabeled monoclonal antibodies.

Author(s): Amaury Guillou; Daniel F. Earley; Malay Patra; Malay Patra; Jason P. Holland
Published in: Nature Protocols, Issue 12, 2020, Page(s) 3579–3594, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-0386-5

Automated light-induced synthesis of 89Zr-radiolabeled antibodies for immuno-positron emission tomography

Author(s): Klingler, Simon; Holland, Jason P.
Published in: Scientific Reports, Issue 12, 2022, Page(s) 668, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-04626-5

Radiochemistry and Preclinical PET Imaging of 68 Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen

Author(s): Eleni Gourni, Luigi Del Pozzo, Mark Bartholomä, Yvonne Kiefer, Philipp T. Meyer, Helmut R. Maecke, Jason P. Holland
Published in: Molecular Imaging, Issue 16, 2017, Page(s) 153601211773701, ISSN 1536-0121
Publisher: Sage Publications Inc.
DOI: 10.1177/1536012117737010

Chemical aspects of metal ion chelation in the synthesis and application antibody-based radiotracers

Author(s): Eszter Boros, Jason P. Holland
Published in: Journal of Labelled Compounds and Radiopharmaceuticals, 2018, ISSN 0362-4803
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3590

Advanced Methods for Radiolabeling Multimodality Nanomedicines for SPECT/MRI and PET/MRI

Author(s): Jennifer Lamb, Jason P. Holland
Published in: Journal of Nuclear Medicine, Issue 59/3, 2018, Page(s) 382-389, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.116.187419

Gallium Complexation, Stability, and Bioconjugation of 1,4,7-Triazacyclononane Derived Chelators with Azaheterocyclic Arms

Author(s): Alexander Schmidtke, Tilman Läppchen, Christian Weinmann, Lorenz Bier-Schorr, Manfred Keller, Yvonne Kiefer, Jason P. Holland, Mark D. Bartholomä
Published in: Inorganic Chemistry, Issue 56/15, 2017, Page(s) 9097-9110, ISSN 0020-1669
Publisher: American Chemical Society
DOI: 10.1021/acs.inorgchem.7b01129

Recent applications of a single quadrupole mass spectrometer in 11 C, 18 F and radiometal chemistry

Author(s): Thomas L. Collier, Kenneth Dahl, Nickeisha A. Stephenson, Jason P. Holland, Adam Riley, Steven H. Liang, Neil Vasdev
Published in: Journal of Fluorine Chemistry, Issue 210, 2018, Page(s) 46-55, ISSN 0022-1139
Publisher: Elsevier BV
DOI: 10.1016/j.jfluchem.2018.02.009

In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate-specific membrane antigen targeting vector

Author(s): Tilman Läppchen, Yvonne Kiefer, Jason P. Holland, Mark D. Bartholomä
Published in: Nuclear Medicine and Biology, Issue 60, 2018, Page(s) 45-54, ISSN 0969-8051
Publisher: Elsevier BV
DOI: 10.1016/j.nucmedbio.2018.03.002

Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me

Author(s): Tilman Läppchen, Jason P. Holland, Yvonne Kiefer, Mark D. Bartholomä
Published in: EJNMMI Radiopharmacy and Chemistry, Issue 3/1, 2018, ISSN 2365-421X
Publisher: Springer
DOI: 10.1186/s41181-018-0043-2

Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me

Author(s): Christian Weinmann, Jason P. Holland, Tilman Läppchen, Harald Scherer, Stephan Maus, Tobias Stemler, Hendrik Bohnenberger, Samer Ezziddin, Philipp Kurz, Mark D. Bartholomä
Published in: Organic & Biomolecular Chemistry, Issue 16/40, 2018, Page(s) 7503-7512, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ob01981a

Photochemische Konjugation und Eintopfradiomarkierung von Antikörpern für Immun-PET

Author(s): Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland
Published in: Angewandte Chemie, Issue 131/7, 2019, Page(s) 1946-1951, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201813287

Frontispiece: Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET

Author(s): Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland
Published in: Angewandte Chemie International Edition, Issue 58/7, 2019, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201980761

Antibody-based radiopharmaceuticals for imaging and therapy

Author(s): Jason P. Holland
Published in: Journal of Labelled Compounds and Radiopharmaceuticals, Issue 61/9, 2018, Page(s) 610-610, ISSN 0362-4803
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/jlcr.3636

Chemical Kinetics of Radiolabelling Reactions

Author(s): Jason P. Holland
Published in: Chemistry - A European Journal, Issue 24/62, 2018, Page(s) 16472-16483, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201803261

Photoactive chelates for radiolabelling proteins

Author(s): Larissa S. Eichenberger, Malay Patra, Jason P. Holland
Published in: Chemical Communications, Issue 55/16, 2019, Page(s) 2257-2260, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8cc09660k

Simultaneous Photoradiochemical Labeling of Antibodies for Immuno-Positron Emission Tomography

Author(s): Malay Patra, Simon Klingler, Larissa S. Eichenberger, Jason P. Holland
Published in: iScience, Issue 13, 2019, Page(s) 416-431, ISSN 2589-0042
Publisher: Elsevier Inc.
DOI: 10.1016/j.isci.2019.03.004

The impact of emerging bioconjugation chemistries on radiopharmaceuticals

Author(s): Rachael Fay, Jason P. Holland
Published in: Journal of Nuclear Medicine, Issue 12, 2019, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.220806

Photochemical Conjugation and One-Pot Radiolabelling of Antibodies for Immuno-PET

Author(s): Malay Patra, Larissa S. Eichenberger, Gregor Fischer, Jason P. Holland
Published in: Angewandte Chemie International Edition, Issue 58/7, 2019, Page(s) 1928-1933, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201813287

Photoradiosynthesis of 68 Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors

Author(s): Rachael Fay, Melanie Gut, Jason P. Holland
Published in: Bioconjugate Chemistry, Issue 30/6, 2019, Page(s) 1814-1820, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00342

The Role of Molecular Imaging in Personalised Healthcare

Author(s): JasonP. Holland
Published in: CHIMIA International Journal for Chemistry, Issue 70/11, 2016, Page(s) 787-795, ISSN 0009-4293
Publisher: Schweizerische Chemische Gedellschaft
DOI: 10.2533/chimia.2016.787

Expanding the chemistry palette for radiotracer synthesis

Author(s): Lamb, Jennifer; d’Orchymont, Faustine; Fay, Rachael; Gribi, Florian; Esteban Flores, Jose; Gut, Melanie; Klingler, Simon; Pires, Patricia; Bühler, Jan; Behmaneshfar, Shamisa; Guillou, Amaury; Earley, Daniel F.; Holland, Jason P.
Published in: Chimia, Issue 12, 2020, Page(s) 946-952, ISSN 2673-2424
Publisher: Chimia
DOI: 10.2533/chimia.2020.946

PhotoTag: Photoactivatable Fluorophores for Protein Labeling

Author(s): Fay, Rachael; Linden, Anthony; Holland, Jason P
Published in: Organic Letters, Issue 12, 2020, Page(s) 3499-3503, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.5167/uzh-187052