Integrated next-generation flow cytometry and sequencing to uncover the pathway of curability in multiple myeloma

Project Information

MYELOMANEXT

Grant agreement ID: 680200

DOI 10.3030/680200

Project closed

EC signature date 11 August 2016

Start date 1 September 2016

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 468 606,00

EU contribution € 1 468 606,00

Coordinated by

UNIVERSIDAD DE NAVARRA
Spain

Publications

Peer reviewed articles (16)

Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma.

Author(s): Noemi Puig; Juan Flores-Montero; Leire Burgos; Maria-Teresa Cedena; Lourdes Cordón; José-Juan Pérez; Luzalba Sanoja-Flores; Irene Manrique; Paula Rodriguez-Otero; Laura Rosiñol; Joaquin Martinez-Lopez; Maria-Victoria Mateos; Juan José Lahuerta; Joan Bladé; Jesús F. San Miguel; Alberto Orfao; Bruno Paiva
Published in: Cancers, Issue Volume 13, 2021, Page(s) 4924, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13194924

Immune biomarkers to predict SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies

Author(s): Luis-Esteban Tamariz-Amador, Anna Martina Battaglia, Catarina Maia, Anastasiia Zherniakova, Camila Guerrero, Aintzane Zabaleta, Leire Burgos, Cirino Botta, Maria-Antonia Fortuño, Carlos Grande, Andrea Manubens, Jose-Maria Arguiñano, Clara Gomez, Ernesto Perez-Persona, Iñigo Olazabal, Itziar Oiartzabal, Carlos Panizo, Felipe Prosper, Jesus F. San-Miguel, Paula Rodriguez-Otero, Esperanza Martín-
Published in: Blood Cancer Journal, Issue Volume 11(12); 2021 Dec, 2021, ISSN 2044-5385
Publisher: Nature Publishing Group
DOI: 10.1038/s41408-021-00594-1

A Machine Learning Model Based on Tumor and Immune Biomarkers to Predict Undetectable MRD and Survival Outcomes in Multiple Myeloma

Author(s): Camila Guerrero; Noemi Puig; Maria-Teresa Cedena; Ibai Goicoechea; Cristina Perez; Juan-José Garcés; Cirino Botta ; Maria-Jose Calasanz; Norma C. Gutierrez; Maria-Luisa Martin-Ramos; Albert Oriol; Rafael Rios; Miguel-Teodoro Hernandez; Rafael Martinez-Martinez; Joan Bargay; Felipe de Arriba; Luis Palomera; Ana Pilar Gonzalez-Rodriguez; Adrian Mosquera-Orgueira; Marta-Sonia Gonzalez-Perez; Joaqui
Published in: Clinical Cancer Research, Issue February 7 2022, 2022, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-21-3430

Depth of Response in Multiple Myeloma: A Pooled Analysis of Three PETHEMA/GEM Clinical Trials

Author(s): Lahuerta, JJ; Paiva, B; Vidriales, MB; Cordon, L; Cedena, MT; Puig, N; Martinez-Lopez, J; Rosiñol L; Gutierrez, NC; Martin-Ramos, ML; Oriol, A; Teruel, AI; Echeveste, MA; de Paz, R; de Arriba, F; Hernandez, MT; Palomera, L; Martinez, R; Martin, A; Alegre, A; De la Rubia, J; Orfao, A; Mateos, MV; Blade, J; San-Miguel, JF; GEM (Grupo Español de Mieloma)/PETHEMA (Programa para el Estudio de la Tera
Published in: Journal of Clinical Oncology, Issue Volume 35, Issue 25, 2017, Page(s) 2900-2910, ISSN 0732-183X
Publisher: American Society of Clinical Oncology
DOI: 10.1200/jco.2016.69.2517

Tumor cells in light-chain amyloidosis and myeloma show distinct transcriptional rewiring of normal plasma cell development

Author(s): Daniel Alameda, Ibai Goicoechea, Marco Vicari, Elena Arriazu, Alice Nevone, Sara Rodriguez, Marta Lasa, Noemi Puig, Maria Teresa Cedena, Diego Alignani, Sonia Garate, David Lara-Astiaso, Amaia Vilas-Zornoza, Sarai Sarvide, Enrique M. Ocio, Ramon Lecumberri, Alfonso Garcia de Coca, Jorge Labrador, Maria-Esther Gonzalez, Luis Palomera, Mercedes Gironella, Valentin Cabañas, Maria Casanova, Albert Or
Published in: Blood Advances, Issue Volume 138, Issue 17, 2021, Page(s) 1583–1589, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020009754

Measurable Residual Disease by Next-Generation Flow Cytometry in Multiple Myeloma

Author(s): Bruno Paiva; Noemi Puig; Maria-Teresa Cedena; Laura Rosiñol; Lourdes Cordón; María-Belén Vidriales; Leire Burgos; Juan Flores-Montero; Juan Flores-Montero; Luzalba Sanoja-Flores; Luzalba Sanoja-Flores; Lucia Lopez-Anglada; Roberto Maldonado; Javier de la Cruz; Norma C. Gutiérrez; Maria-Jose Calasanz; María-Luisa Martín-Ramos; Ramón García-Sanz; Joaquin Martinez-Lopez; Albert Oriol; M.J. B
Published in: Journal of Clinical Oncology, Issue Volume 38, Issue 8, 2020, Page(s) 784-792, ISSN 0732-183X
Publisher: American Society of Clinical Oncology
DOI: 10.1200/jco.19.01231

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma

Author(s): Yuji Mishima, Bruno Paiva, Jiantao Shi, Jihye Park, Salomon Manier, Satoshi Takagi, Mira Massoud, Adriana Perilla-Glen, Yosra Aljawai, Daisy Huynh, Aldo M. Roccaro, Antonio Sacco, Marzia Capelletti, Alexandre Detappe, Diego Alignani, Kenneth C. Anderson, Nikhil C. Munshi, Felipe Prosper, Jens G. Lohr, Gavin Ha, Samuel S. Freeman, Eliezer M. Van Allen, Viktor A. Adalsteinsson, Franziska Michor, Jes
Published in: Cell Reports, Issue 19/1, 2017, Page(s) 218-224, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2017.03.025

Prognostic value of antigen expression in multiple myeloma: a PETHEMA/GEM study on 1265 patients enrolled in four consecutive clinical trials

Author(s): P Arana, B Paiva, M-T Cedena, N Puig, L Cordon, M-B Vidriales, N C Gutierrez, F Chiodi, L Burgos, L-L Anglada, J Martinez-Lopez, M-T Hernandez, A-I Teruel, M Gironella, M-A Echeveste, L Rosiñol, R Martinez, A Oriol, J De la Rubia, A Orfao, J Blade, J-J Lahuerta, M-V Mateos, J-F San Miguel
Published in: Leukemia, Issue 32/4, 2017, Page(s) 971-978, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2017.320

Phenotypic and genomic analysis of multiple myeloma minimal residual disease tumor cells: a new model to understand chemoresistance

Author(s): B. Paiva, L. A. Corchete, M.-B. Vidriales, N. Puig, P. Maiso, I. Rodriguez, D. Alignani, L. Burgos, M.-L. Sanchez, P. Barcena, M.-A. Echeveste, M. T. Hernandez, R. Garcia-Sanz, E. M. Ocio, A. Oriol, M. Gironella, L. Palomera, F. De Arriba, Y. Gonzalez, S. K. Johnson, J. Epstein, B. Barlogie, J. J. Lahuerta, J. Blade, A. Orfao, M.-V. Mateos, J. F. San Miguel
Published in: Blood, Issue 127/15, 2016, Page(s) 1896-1906, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2015-08-665679

Current applications of multiparameter flow cytometry in plasma cell disorders

Author(s): T Jelinek, R Bezdekova, M Zatopkova, L Burgos, M Simicek, T Sevcikova, B Paiva, R Hajek
Published in: Blood Cancer Journal, Issue 7/10, 2017, Page(s) e617, ISSN 2044-5385
Publisher: Nature Publishing Group
DOI: 10.1038/bcj.2017.90

Differentiation stage of myeloma plasma cells: biological and clinical significance

Author(s): B Paiva, N Puig, M T Cedena, B G de Jong, Y Ruiz, I Rapado, J Martinez-Lopez, L Cordon, D Alignani, J A Delgado, M C van Zelm, J J M Van Dongen, M Pascual, X Agirre, F Prosper, J I Martín-Subero, M-B Vidriales, N C Gutierrez, M T Hernandez, A Oriol, M A Echeveste, Y Gonzalez, S K Johnson, J Epstein, B Barlogie, G J Morgan, A Orfao, J Blade, M V Mateos, J J Lahuerta, J F San-Miguel
Published in: Leukemia, Issue 31/2, 2017, Page(s) 382-392, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/leu.2016.211

Utility of flow cytometry studies in the management of patients with multiple myeloma

Author(s): Bruno Paiva, Juana Merino, Jesús F. San Miguel
Published in: Current Opinion in Oncology, Issue 28/6, 2016, Page(s) 511-517, ISSN 1040-8746
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/cco.0000000000000331

Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma

Author(s): Juan-José Garcés, Gabriel Bretones, Leire Burgos, Rafael Valdes-Mas, Noemi Puig, Maria-Teresa Cedena, Diego Alignani, Idoia Rodriguez, Diana Álvarez Puente, Miguel-García Álvarez, Ibai Goicoechea, Sara Rodriguez, Maria-Jose Calasanz, Xabier Agirre, Juan Flores-Montero, Luzalba Sanoja-Flores, Paula Rodriguez-Otero, Rafael Rios, Joaquin Martinez-Lopez, Pamela Millacoy, Luis Palomera, Rafael Del
Published in: Leukemia, Issue 34/11, 2020, Page(s) 3007-3018, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-020-0883-0

Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients

Author(s): Esperanza Martín-Sánchez, Juan José Garcés, Catarina Maia, Susana Inogés, Ascensión López-Díaz de Cerio, Francisco Carmona-Torre, Marta Marin-Oto, Félix Alegre, Elvira Molano, Mirian Fernandez-Alonso, Cristina Perez, Cirino Botta, Aintzane Zabaleta, Ana Belen Alcaide, Manuel F. Landecho, Marta Rua, Teresa Pérez-Warnisher, Laura Blanco, Sarai Sarvide, Amaia Vilas-Zornoza, Diego Alignani,
Published in: Frontiers in Immunology, Issue 12, 2021, ISSN 1664-3224
Publisher: Frontiers in immunology
DOI: 10.3389/fimmu.2021.659018

Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination

Author(s): Juan-Jose Garcés, Michal Simicek, Marco Vicari, Lucie Brozova, Leire Burgos, Renata Bezdekova, Diego Alignani, Maria-Jose Calasanz, Katerina Growkova, Ibai Goicoechea, Xabier Agirre, Ludek Pour, Felipe Prosper, Rafael Rios, Joaquin Martinez-Lopez, Pamela Millacoy, Luis Palomera, Rafael Del Orbe, Albert Perez-Montaña, Sonia Garate, Laura Blanco, Marta Lasa, Patricia Maiso, Juan Flores-Montero, Lu
Published in: Leukemia, Issue 34/2, 2020, Page(s) 589-603, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0588-4

FlowCT for the analysis of large immunophenotypic data sets and biomarker discovery in cancer immunology

Author(s): Cirino Botta, Catarina Maia, Juan-José Garcés, Rosalinda Termini, Cristina Perez, Irene Manrique, Leire Burgos, Aintzane Zabaleta, Diego Alignani, Sarai Sarvide, Juana Merino, Noemi Puig, María-Teresa Cedena, Marco Rossi, Pierfrancesco Tassone, Massimo Gentile, Pierpaolo Correale, Ivan Borrello, Evangelos Terpos, Tomas Jelinek, Artur Paiva, Aldo Roccaro, Hartmut Goldschmidt, Hervé Avet-Loiseau
Published in: Blood Advances, Issue Volume 6, Issue 2, 2022, Page(s) 690–703, ISSN 2473-9529
Publisher: Blood advances
DOI: 10.1182/bloodadvances.2021005198