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Pathophysiology of Primary Aldosteronism

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Publications

Diverse Responses of Autoantibodies to the Angiotensin II Type 1 Receptor in Primary Aldosteronism

Author(s): Tracy Ann Williams, Diana Jaquin, Jacopo Burrello, Aurélie Philippe, Yuhong Yang, Petra Rank, Nina Nirschl, Lisa Sturm, Christoph Hübener, Duska Dragun, Martin Bidlingmaier, Felix Beuschlein, Martin Reincke
Published in: Hypertension, Issue 74/4, 2019, Page(s) 784-792, ISSN 0194-911X
DOI: 10.1161/hypertensionaha.119.13156

Lipoprotein insulin resistance score and branched-chain amino acids increase after adrenalectomy for unilateral aldosterone-producing adenoma: a preliminary study

Author(s): Christian Adolf, Annika M. A. Berends, Margery A. Connelly, Martin Reincke, Robin P. F. Dullaart
Published in: Endocrine, Issue 68/2, 2020, Page(s) 420-426, ISSN 1355-008X
DOI: 10.1007/s12020-020-02235-2

Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations

Author(s): Yoshikiyo Ono, Yuto Yamazaki, Kei Omata, Tobias Else, Scott A Tomlins, Yara Rhayem, Tracy Ann Williams, Martin Reincke, Tobias Carling, Silvia Monticone, Paolo Mulatero, Felix Beuschlein, Sadayoshi Ito, Fumitoshi Satoh, William E Rainey, Hironobu Sasano
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 105/3, 2020, Page(s) e282-e289, ISSN 0021-972X
DOI: 10.1210/clinem/dgz235

Effect of Dietary Sodium Modulation on Pig Adrenal Steroidogenesis and Transcriptome Profiles

Author(s): Twinkle Vohra, Elisabeth Kemter, Na Sun, Britta Dobenecker, Arne Hinrichs, Jacopo Burrello, Elise P. Gomez-Sanchez, Celso E. Gomez-Sanchez, Jun Wang, Isabella-Sabrina Kinker, Daniel Teupser, Konrad Fischer, Angelika Schnieke, Mirko Peitzsch, Graeme Eisenhofer, Axel Walch, Martin Reincke, Eckhard Wolf, Tracy Ann Williams
Published in: Hypertension, Issue 76/6, 2020, Page(s) 1769-1777, ISSN 0194-911X
DOI: 10.1161/hypertensionaha.120.15998

Use of Steroid Profiling Combined With Machine Learning for Identification and Subtype Classification in Primary Aldosteronism

Author(s): Graeme Eisenhofer, Claudio Durán, Carlo Vittorio Cannistraci, Mirko Peitzsch, Tracy Ann Williams, Anna Riester, Jacopo Burrello, Fabrizio Buffolo, Aleksander Prejbisz, Felix Beuschlein, Andrzej Januszewicz, Paolo Mulatero, Jacques W. M. Lenders, Martin Reincke
Published in: JAMA Network Open, Issue 3/9, 2020, Page(s) e2016209, ISSN 2574-3805
DOI: 10.1001/jamanetworkopen.2020.16209

International Histopathology Consensus for Unilateral Primary Aldosteronism

Author(s): Tracy Ann Williams, Celso E Gomez-Sanchez, William E Rainey, Thomas J Giordano, Alfred K Lam, Alison Marker, Ozgur Mete, Yuto Yamazaki, Maria Claudia Nogueira Zerbini, Felix Beuschlein, Fumitoshi Satoh, Jacopo Burrello, Holger Schneider, Jacques W M Lenders, Paolo Mulatero, Isabella Castellano, Thomas Knösel, Mauro Papotti, Wolfgang Saeger, Hironobu Sasano, Martin Reincke
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 106/1, 2020, Page(s) 42-54, ISSN 0021-972X
DOI: 10.1210/clinem/dgaa484

Progress in Primary Aldosteronism 2019: New Players on theBlock?

Author(s): Martin Reincke, Felix Beuschlein, Tracy Ann Williams
Published in: Hormone and Metabolic Research, Issue 52/06, 2020, Page(s) 345-346, ISSN 0018-5043
DOI: 10.1055/a-1156-9926

Single-Center Prospective Cohort Study on the Histopathology, Genotype, and Postsurgical Outcomes of Patients With Primary Aldosteronism

Author(s): Lucie S. Meyer, Laura Handgriff, Jung Soo Lim, Aaron M. Udager, Isabella-Sabrina Kinker, Roland Ladurner, Moritz Wildgruber, Thomas Knösel, Martin Bidlingmaier, William E. Rainey, Martin Reincke, Tracy Ann Williams
Published in: Hypertension, Issue 78/3, 2021, Page(s) 738-746, ISSN 0194-911X
DOI: 10.1161/hypertensionaha.121.17348

THERAPY OF ENDOCRINE DISEASE: Medical treatment of primary aldosteronism

Author(s): Benjamin Lechner, Katharina Lechner, Daniel Heinrich, Christian Adolf, Finn Holler, Holger Schneider, Felix Beuschlein, Martin Reincke
Published in: European Journal of Endocrinology, Issue 181/4, 2019, Page(s) R147-R153, ISSN 0804-4643
DOI: 10.1530/eje-19-0215

Circulating miRNA Expression Profiling in Primary Aldosteronism

Author(s): Abel Decmann, Gábor Nyírö, Ottó Darvasi, Péter Turai, Irina Bancos, Ravinder Jeet Kaur, Raffaele Pezzani, Maurizio Iacobone, Ivana Kraljevic, Darko Kastelan, Mirko Parasiliti-Caprino, Mauro Maccario, Nina Nirschl, Daniel Heinrich, Martin Reincke, Attila Patócs, Peter Igaz
Published in: Frontiers in Endocrinology, Issue 10, 2019, ISSN 1664-2392
DOI: 10.3389/fendo.2019.00739

Primary Aldosteronism

Author(s): Yuhong Yang, Celso E. Gomez-Sanchez, Diana Jaquin, Elke Tatjana Aristizabal Prada, Lucie S. Meyer, Thomas Knösel, Holger Schneider, Felix Beuschlein, Martin Reincke, Tracy Ann Williams
Published in: Hypertension, Issue 74/4, 2019, Page(s) 809-816, ISSN 0194-911X
DOI: 10.1161/hypertensionaha.119.13476

Plasma Steroid Profiles in Subclinical Compared With Overt Adrenal Cushing Syndrome

Author(s): Jimmy Masjkur, Matthias Gruber, Mirko Peitzsch, Denise Kaden, Guido Di Dalmazi, Martin Bidlingmaier, Stephanie Zopp, Katharina Langton, Julia Fazel, Felix Beuschlein, Stefan Richard Bornstein, Martin Reincke, Graeme Eisenhofer
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 104/10, 2019, Page(s) 4331-4340, ISSN 0021-972X
DOI: 10.1210/jc.2018-02349

Prevalence, diagnosis and outcomes of treatment for primary aldosteronism

Author(s): Yuhong Yang, Martin Reincke, Tracy Ann Williams
Published in: Best Practice & Research Clinical Endocrinology & Metabolism, Issue 34/2, 2020, Page(s) 101365, ISSN 1521-690X
DOI: 10.1016/j.beem.2019.101365

Spironolactone reduces biochemical markers of bone turnover in postmenopausal women with primary aldosteronism

Author(s): Christian Adolf, Leah T. Braun, Carmina T. Fuss, Stefanie Hahner, Heike Künzel, Laura Handgriff, Lisa Sturm, Daniel A. Heinrich, Holger Schneider, Martin Bidlingmaier, Martin Reincke
Published in: Endocrine, Issue 69/3, 2020, Page(s) 625-633, ISSN 1355-008X
DOI: 10.1007/s12020-020-02348-8

Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology

Author(s): Leticia Aragao-Santiago, Celso E Gomez-Sanchez, Paolo Mulatero, Ariadni Spyroglou, Martin Reincke, Tracy Ann Williams
Published in: Endocrinology, Issue 158/12, 2017, Page(s) 4129-4138, ISSN 0013-7227
DOI: 10.1210/en.2017-00637

Old and New Concepts in the Molecular Pathogenesis of Primary Aldosteronism

Author(s): Elke Tatjana Aristizabal Prada, Jacopo Burrello, Martin Reincke, Tracy Ann Williams
Published in: Hypertension, Issue 70/5, 2017, Page(s) 875-881, ISSN 0194-911X
DOI: 10.1161/HYPERTENSIONAHA.117.10111

Subtyping of Patients with Primary Aldosteronism: An Update

Author(s): Jacques Lenders, Graeme Eisenhofer, Martin Reincke
Published in: Hormone and Metabolic Research, Issue 49/12, 2017, Page(s) 922-928, ISSN 0018-5043
DOI: 10.1055/s-0043-122602

Disordered CYP11B2 Expression in Primary Aldosteronism

Author(s): Celso Gomez-Sanchez, Maniselvan Kuppusamy, Martin Reincke, Tracy Williams
Published in: Hormone and Metabolic Research, Issue 49/12, 2017, Page(s) 957-962, ISSN 0018-5043
DOI: 10.1055/s-0043-122238

Diagnosis and Treatment of Primary Aldosteronism in 2017: Did We Achieve Our Goals?

Author(s): Martin Reincke, Tracy Williams, Felix Beuschlein
Published in: Hormone and Metabolic Research, Issue 49/12, 2017, Page(s) 905-907, ISSN 0018-5043
DOI: 10.1055/s-0043-122145

DIAGNOSIS OF ENDOCRINE DISEASE: 18-Oxocortisol and 18-hydroxycortisol: is there clinical utility of these steroids?

Author(s): Jacques W M Lenders, Tracy Ann Williams, Martin Reincke, Celso E Gomez-Sanchez
Published in: European Journal of Endocrinology, Issue 178/1, 2017, Page(s) R1-R9, ISSN 0804-4643
DOI: 10.1530/EJE-17-0563

Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism

Author(s): Elke Aristizabal Prada, Isabella Castellano, Eva Sušnik, Yuhong Yang, Lucie Meyer, Martina Tetti, Felix Beuschlein, Martin Reincke, Tracy Williams
Published in: International Journal of Molecular Sciences, Issue 19/4, 2018, Page(s) 1124, ISSN 1422-0067
DOI: 10.3390/ijms19041124

Anxiety, Depression, and Impaired Quality of Life in Primary Aldosteronism: Why We Shouldn’t Ignore It!

Author(s): Martin Reincke
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 103/1, 2017, Page(s) 1-4, ISSN 0021-972X
DOI: 10.1210/jc.2017-02141

MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited

Author(s): Tracy Ann Williams, Martin Reincke
Published in: European Journal of Endocrinology, Issue 179/1, 2018, Page(s) R19-R29, ISSN 0804-4643
DOI: 10.1530/EJE-17-0990

Primary Aldosteronism and Cardiovascular Events

Author(s): Martin Reincke
Published in: Hypertension, Issue 71/3, 2018, Page(s) 413-414, ISSN 0194-911X
DOI: 10.1161/HYPERTENSIONAHA.117.10405

Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma

Author(s): Britta Heinze, Carmina T. Fuss, Paolo Mulatero, Felix Beuschlein, Martin Reincke, Mona Mustafa, Andreas Schirbel, Timo Deutschbein, Tracy Ann Williams, Yara Rhayem, Marcus Quinkler, Nada Rayes, Silvia Monticone, Vanessa Wild, Celso E. Gomez-Sanchez, Anna-Carinna Reis, Stephan Petersenn, Hans-Juergen Wester, Saskia Kropf, Martin Fassnacht, Katharina Lang, Ken Herrmann, Andreas K. Buck, Christina Bl
Published in: Hypertension, Issue 71/2, 2018, Page(s) 317-325, ISSN 0194-911X
DOI: 10.1161/hypertensionaha.117.09975

The Adrenal Gland: Central Relay in Health and Disease

Author(s): Martin Reincke, Felix Beuschlein, Stefan Bornstein, Graeme Eisenhofer, Martin Fassnacht, Nicole Reisch, Tracy Williams
Published in: Experimental and Clinical Endocrinology & Diabetes, Issue 127/02/03, 2019, Page(s) 81-83, ISSN 0947-7349
DOI: 10.1055/a-0752-4176

Inherited Forms of Primary Hyperaldosteronism: New Genes, New Phenotypes and Proposition of A New Classification

Author(s): Luis Perez-Rivas, Tracy Williams, Martin Reincke
Published in: Experimental and Clinical Endocrinology & Diabetes, Issue 127/02/03, 2019, Page(s) 93-99, ISSN 0947-7349
DOI: 10.1055/a-0713-0629

The Primary Aldosteronism Surgical Outcome Score for the Prediction of Clinical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism

Author(s): Jacopo Burrello, Alessio Burrello, Michael Stowasser, Tetsuo Nishikawa, Marcus Quinkler, Aleksander Prejbisz, Jacques W. M. Lenders, Fumitoshi Satoh, Paolo Mulatero, Martin Reincke, Tracy Ann Williams
Published in: Annals of Surgery, 2019, Page(s) 1, ISSN 0003-4932
DOI: 10.1097/sla.0000000000003200

Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort

Author(s): Tracy A Williams, Jacques W M Lenders, Paolo Mulatero, Jacopo Burrello, Marietta Rottenkolber, Christian Adolf, Fumitoshi Satoh, Laurence Amar, Marcus Quinkler, Jaap Deinum, Felix Beuschlein, Kanako K Kitamoto, Uyen Pham, Ryo Morimoto, Hironobu Umakoshi, Aleksander Prejbisz, Tomaz Kocjan, Mitsuhide Naruse, Michael Stowasser, Tetsuo Nishikawa, William F Young, Celso E Gomez-Sanchez, John W Funder,
Published in: The Lancet Diabetes & Endocrinology, Issue 5/9, 2017, Page(s) 689-699, ISSN 2213-8587
DOI: 10.1016/s2213-8587(17)30135-3

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

Author(s): Wiebke Arlt, Katharina Lang, Alice J. Sitch, Anna S. Dietz, Yara Rhayem, Irina Bancos, Annette Feuchtinger, Vasileios Chortis, Lorna C. Gilligan, Philippe Ludwig, Anna Riester, Evelyn Asbach, Beverly A. Hughes, Donna M. O’Neil, Martin Bidlingmaier, Jeremy W. Tomlinson, Zaki K. Hassan-Smith, D. Aled Rees, Christian Adolf, Stefanie Hahner, Marcus Quinkler, Tanja Dekkers, Jaap Deinum, Michael Biehl
Published in: JCI Insight, Issue 2/8, 2017, ISSN 2379-3708
DOI: 10.1172/jci.insight.93136

Treatment of Unilateral PA by Adrenalectomy: Potential Reasons for Incomplete Biochemical Cure

Author(s): Yuhong Yang, Martin Reincke, Tracy Williams
Published in: Experimental and Clinical Endocrinology & Diabetes, Issue 127/02/03, 2019, Page(s) 100-108, ISSN 0947-7349
DOI: 10.1055/a-0662-6081

Classification of microadenomas in patients with primary aldosteronism by steroid profiling

Author(s): Yuhong Yang, Jacopo Burrello, Alessio Burrello, Graeme Eisenhofer, Mirko Peitzsch, Martina Tetti, Thomas Knösel, Felix Beuschlein, Jacques W.M. Lenders, Paolo Mulatero, Martin Reincke, Tracy Ann Williams
Published in: The Journal of Steroid Biochemistry and Molecular Biology, 2019, ISSN 0960-0760
DOI: 10.1016/j.jsbmb.2019.01.008

Computed Tomography and Adrenal Venous Sampling in the Diagnosis of Unilateral Primary Aldosteronism

Author(s): Tracy A. Williams, Jacopo Burrello, Leonardo A. Sechi, Carlos E. Fardella, Joanna Matrozova, Christian Adolf, René Baudrand, Stella Bernardi, Felix Beuschlein, Cristiana Catena, Michalis Doumas, Francesco Fallo, Gilberta Giacchetti, Daniel A. Heinrich, Gaëlle Saint-Hilary, Pieter M. Jansen, Andrzej Januszewicz, Tomaz Kocjan, Tetsuo Nishikawa, Marcus Quinkler, Fumitoshi Satoh, Hironobu Umakoshi,
Published in: Hypertension, Issue 72/3, 2018, Page(s) 641-649, ISSN 0194-911X
DOI: 10.1161/HYPERTENSIONAHA.118.11382

Immunohistopathology and Steroid Profiles Associated With Biochemical Outcomes After Adrenalectomy for Unilateral Primary Aldosteronism

Author(s): Lucie S. Meyer, Xiao Wang, Eva Sušnik, Jacopo Burrello, Alessio Burrello, Isabella Castellano, Graeme Eisenhofer, Francesco Fallo, Gregory A. Kline, Thomas Knösel, Tomaz Kocjan, Jacques W.M. Lenders, Paolo Mulatero, Mitsuhide Naruse, Tetsuo Nishikawa, Mirko Peitzsch, Lars C. Rump, Felix Beuschlein, Stefanie Hahner, Celso E. Gomez-Sanchez, Martin Reincke, Tracy Ann Williams
Published in: Hypertension, Issue 72/3, 2018, Page(s) 650-657, ISSN 0194-911X
DOI: 10.1161/hypertensionaha.118.11465

Cortisol Excess in Patients With Primary Aldosteronism Impacts Left Ventricular Hypertrophy

Author(s): Christian Adolf, Anton Köhler, Anna Franke, Katharina Lang, Anna Riester, Anja Löw, Daniel A Heinrich, Martin Bidlingmaier, Marcus Treitl, Roland Ladurner, Felix Beuschlein, Wiebke Arlt, Martin Reincke
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 103/12, 2018, Page(s) 4543-4552, ISSN 0021-972X
DOI: 10.1210/jc.2018-00617

Patients With Primary Aldosteronism Respond to Unilateral Adrenalectomy With Long-Term Reduction in Salt Intake

Author(s): Christian Adolf, Daniel A Heinrich, Finn Holler, Benjamin Lechner, Nina Nirschl, Lisa Sturm, Veronika Görge, Anna Riester, Tracy A Williams, Marcus Treitl, Roland Ladurner, Felix Beuschlein, Martin Reincke
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 105/3, 2020, Page(s) e484-e493, ISSN 0021-972X
DOI: 10.1210/clinem/dgz051

In situ metabolomics of aldosterone-producing adenomas

Author(s): Masanori Murakami, Yara Rhayem, Thomas Kunzke, Na Sun, Annette Feuchtinger, Philippe Ludwig, Tim Matthias Strom, Celso Gomez-Sanchez, Thomas Knösel, Thomas Kirchner, Tracy Ann Williams, Martin Reincke, Axel Karl Walch, Felix Beuschlein
Published in: JCI Insight, Issue 4/17, 2019, ISSN 2379-3708
DOI: 10.1172/jci.insight.130356

BEX1 Is Differentially Expressed in Aldosterone-Producing Adenomas and Protects Human Adrenocortical Cells From Ferroptosis

Author(s): Yuhong Yang, Martina Tetti, Twinkle Vohra, Christian Adolf, Jochen Seissler, Michael Hristov, Alexia Belavgeni, Martin Bidlingmaier, Andreas Linkermann, Paolo Mulatero, Felix Beuschlein, Martin Reincke, Tracy Ann Williams
Published in: Hypertension, Issue 77/5, 2021, Page(s) 1647-1658, ISSN 0194-911X
DOI: 10.1161/hypertensionaha.120.16774

Salt Appetite and its Effects on Cardiovascular Risk in Primary Aldosteronism

Author(s): Christian Adolf, Holger Schneider, Daniel A. Heinrich, Laura Handgriff, Martin Reincke
Published in: Hormone and Metabolic Research, Issue 52/06, 2020, Page(s) 386-393, ISSN 0018-5043
DOI: 10.1055/a-1116-2407

Adrenal Insufficiency After Unilateral Adrenalectomy in Primary Aldosteronism: Long-Term Outcome and Clinical Impact

Author(s): Daniel A Heinrich, Christian Adolf, Finn Holler, Benjamin Lechner, Holger Schneider, Anna Riester, Nina Nirschl, Lisa Sturm, Xiao Wang, Roland Ladurner, Max Seidensticker, Martin Bidlingmaier, Felix Beuschlein, Martin Reincke
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 104/11, 2019, Page(s) 5658-5664, ISSN 0021-972X
DOI: 10.1210/jc.2019-00996

Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism

Author(s): Lukas Engler, Christian Adolf, Daniel A Heinrich, Anna-Katharine Brem, Anna Riester, Anna Franke, Felix Beuschlein, Martin Reincke, Axel Steiger, Heike Künzel
Published in: Endocrine Connections, Issue 8/4, 2019, Page(s) 407-415, ISSN 2049-3614
DOI: 10.1530/ec-19-0043

Characteristics of preoperative steroid profiles and glucose metabolism in patients with primary aldosteronism developing adrenal insufficiency after adrenalectomy

Author(s): Xiao Wang, Daniel A. Heinrich, Sonja L. Kunz, Nina Heger, Lisa Sturm, Olaf Uhl, Felix Beuschlein, Martin Reincke, Martin Bidlingmaier
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
DOI: 10.1038/s41598-021-90901-4

Timeline of Advances in Genetics of Primary Aldosteronism

Author(s): Lucie S. Meyer, Martin Reincke, Tracy Ann Williams
Published in: Genetics of Endocrine Diseases and Syndromes, Issue 111, 2019, Page(s) 213-243
DOI: 10.1007/978-3-030-25905-1_11